Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses
1999; American Association for the Advancement of Science; Volume: 286; Issue: 5438 Linguagem: Inglês
10.1126/science.286.5438.300
ISSN1095-9203
AutoresJunji Uchida, Teruhito Yasui, Yuko Takaoka-Shichijo, Masaaki Muraoka, Wanla Kulwichit, Nancy Raab‐Traub, Hitoshi Kikutani,
Tópico(s)Immune Cell Function and Interaction
ResumoThe effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.
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