THE PENETRATION OF DAPSONE, RIFAMPICIN, ISONIAZID AND PYRAZINAMIDE INTO PERIPHERAL NERVES
1975; Wiley; Volume: 55; Issue: 1 Linguagem: Inglês
10.1111/j.1476-5381.1975.tb07623.x
ISSN1476-5381
AutoresB.W. Allen, G.A. Ellard, Patricia T. Gammon, Robert C. King, A. C. McDOUGALL, R. J. W. Rees, A. G. M. Weddell,
Tópico(s)Hematological disorders and diagnostics
Resumo1 Dapsone, rifampicin, isoniazid and pyrazinamide were shown to penetrate readily into the sciatic nerves of the dog and sheep. 2 These findings suggest that the continued persistence of viable drug-sensitive leprosy bacilli in the peripheral nerves of patients treated for long periods with either dapsone or rifampicin is not due to inadequate intraneural drug penetration.
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