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On the ethionine-induced inhibition of protein synthesis in male and female rats—Lack of effect on intestinal mucosa

1968; Elsevier BV; Volume: 158; Issue: 3 Linguagem: Inglês

10.1016/0304-4165(68)90296-1

1872-8006

Franz F. Schlunk, Daniel S. Longnecker, Benito Lombardi,

Diet, Metabolism, and Disease

1. Ethionine inhibits synthesis of liver and plasma proteins in both male and female rats. Very low density lipoproteins are reduced to a similar degree in both sexes. However, no ethionine-induced inhibition of incorporation in vivo of labeled leucine into proteins of jejunal mucosa is observed. 2. The accumulation of triglycerides in the liver of ethionine-treated rats is significantly greater after oral administration of corn oil than in animals not receiving corn oil. It is concluded that the low levels of plasma triglycerides observed in ethionine-treated rats after feeding corn oil are not a reflection of decreased fat absorption but result mainly from the developing fatty liver which traps chylomicra triglycerides and fails to release them back into the systemic circulation.