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Herpes simplex infection and the risk of Alzheimer's disease: A nested case-control study

2014; Wiley; Volume: 11; Issue: 6 Linguagem: Inglês

10.1016/j.jalz.2014.07.157

1552-5279

Hugo Lövheim, Jonathan D. Gilthorpe, Anders Johansson, Sture Eriksson, Göran Hallmans, Fredrik Elgh,

Acne and Rosacea Treatments and Effects

Herpes simplex virus (HSV) is thought to play an etiological role in the development of Alzheimer's disease (AD).Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years) and 360 age- and sex-matched dementia-free controls, taken on average 9.6 years before AD diagnosis, were analyzed for anti-HSV antibodies (immunoglobulin G, IgG, and immunoglobulin M, IgM) by enzyme-linked immunosorbent assays.In the complete sample group, the presence of anti-HSV IgG and IgM antibodies did not increase the risk of AD significantly (odds ratio (OR) 1.636, P = .069 and OR 1.368, P = .299, respectively). In cases with 6.6 years or more between plasma sampling and AD diagnosis (n = 270), there was a significant association between presence of anti-HSV IgG antibodies and AD (OR 2.250, P = .019).Among persons with a follow-up time of 6.6 years or more, HSV infection was significantly associated with AD.