Produção Nacional
Revisado por pares
Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance
2013; Frontiers Media; Volume: 4; Linguagem: Inglês
10.3389/fmicb.2013.00353
ISSN1664-302X
AutoresFernanda Guilhelmelli, Nathália Vilela, Patrícia Albuquerque, Lorena da Silveira Derengowski, Ildinete Silva-Pereira, Cynthia Maria Kyaw,
Tópico(s)Invertebrate Immune Response Mechanisms
ResumoAntimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such as mammals, arthropods, plants and bacteria. In addition to antimicrobial activity, AMPs can induce chemokine production, accelerate angiogenesis and wound healing and modulate apoptosis in multicellular organisms. Originally, their antimicrobial mechanism of action was thought to consist solely of an increase in pathogen cell membrane permeability, but it has already been shown that several AMPs do not modulate membrane permeability in the minimal lethal concentration. Instead, they exert their effects by inhibiting processes such as protein and cell wall synthesis, as well as enzyme activity, among others. Although resistance to these molecules is uncommon several pathogens developed different strategies to overcome AMPs killing such as surface modification, expression of efflux pumps and secretion of proteases among others. This review describes the various mechanisms of action of AMPs and how pathogens evolve resistance to them.
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