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Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium

2005; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês

10.1016/j.tiv.2005.08.012

1879-3177

Maira Eiko Ikuma Nogueira, Mariana Henrique Passoni, Fabiana Izilda Biso, Maria do Carmo Longo, Cássia Regina Cardoso, Lourdes Campaner dos Santos, Eliana Aparecida Varanda,

Genetically Modified Organisms Research

Melampodium divaricatum is a member of the Asteraceae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold (Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effect in the Salmonella/microsome assay. The tested extract was not mutagenic in the strains TA100, TA98, TA97a and TA102 and decreased the mutagenicity of aflatoxin B1, benzo(a)pyrene and daunomycin. Chlorophyll and triterpenes were detected in the extract, and they might have contributed to the observed effect. Our data suggest that these medicinal plants possess cancer chemopreventive properties.