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Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

2007; Elsevier BV; Volume: 48; Issue: 48 Linguagem: Inglês

10.1016/j.tetlet.2007.09.175

1873-3581

Jalpa C. Trivedi, Jitender Bariwal, Kuldip Upadhyay, Yogesh T. Naliapara, Sudhir K. Joshi, Christophe Pannecouque, Erik De Clercq, Anamik Shah,

Fungal Plant Pathogen Control

Two closely structurally related coumarins, 4-hydroxy-8-isopropyl-5-methylcoumarin and 4-hydroxy-6-chloro-7-methylcoumarin were acylated at C-3 and further converted to the respective chalcones and two series of eighteen new compounds, which were evaluated for possible antiviral activity.