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Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma

2004; Elsevier BV; Volume: 16; Issue: 6 Linguagem: Inglês

10.1016/j.clon.2004.02.007

1433-2981

Richard Soutar, Helen Lucraft, Graham Jackson, A. T. Reece, Jenny Bird, Eric Low, Diana Samson,

Acute Myeloid Leukemia Research

Most patients with plasma cell neoplasia have generalised disease at diagnosis (i.e. multiple myeloma [MM]). However, a few patients (less than 5%) with plasma cell malignancies present with either a single bone lesion, or less commonly, a soft tissue mass of monoclonal plasma cells: solitary plasmacytoma of bone (SBP) or extramedullary plasmacytoma (SEP). SBP has a high risk of progression to MM and, on magnetic resonance imaging (MRI) examination, at least 25% of patients with an apparent solitary lesion have evidence of disease elsewhere [ 1 Moulopoulos L.A. Dimopoulos M.A. Weber D. Fuller L. Libshitz H. Alexanian R. Magnetic resonance imaging in the staging of solitary plasmacytoma of bone. J Clin Oncol. 1993; 11: 1311-1315 PubMed Google Scholar ]. In contrast, SEP is nearly always truly localised and has a high cure rate with local treatment.