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High‐titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors

2002; Wiley; Volume: 71; Issue: 1 Linguagem: Inglês

10.1002/ajh.10172

1096-8652

N. Bayani, Michel Rugina, Laurence Haddad‐Vergnes, F. Lelong,

Hemostasis and retained surgical items

Abstract We report a 79‐year‐old man with two simultaneous malignant tumors (buccal epidermoid carcinoma and prostatic adenocarcinoma) who developed a severe bleeding complication at the site of the buccal tumor as well as a massive cerebral hematoma after a skull trauma. Laboratory findings showed the presence of a high‐titer specific factor V inhibitor. The patient failed to respond to intravenous immunoglobulins, but both clinical and laboratory improvement was obtained after treatment with corticosteroids and cyclophosphamide. Am. J. Hematol. 71:33–36, 2002. © 2002 Wiley‐Liss, Inc.