Aldose Reductase and Advanced Glycation Endproducts Inhibitory Effect of Phyllostachys nigra
2007; Pharmaceutical Society of Japan; Volume: 30; Issue: 8 Linguagem: Inglês
10.1248/bpb.30.1569
ISSN1347-5215
AutoresSang Hoon Jung, Jung Min Lee, Hee Ju Lee, Chul Young Kim, Eun Ha Lee, Byung Hun Um,
Tópico(s)Biochemical effects in animals
ResumoTo evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra, eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6-C-(6″-O-trans-caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem® apparatus. It is concluded, therefore, that luteolin 6-C-(6″-O-trans-caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications.
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