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RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

2009; Public Library of Science; Volume: 4; Issue: 12 Linguagem: Inglês

10.1371/journal.pone.0008210

1932-6203

Paola Sebastiani, Monty Montano, Annibale Alessandro Puca, Nadia Solovieff, Toshio Kojima, Meng C. Wang, Efthymia Melista, Micah Meltzer, Sylvia E. J. Fischer, Stacy L. Andersen, Stephen H. Hartley, Amanda Sedgewick, Yasumichi Arai, Aviv Bergman, Nir Barzilai, Dellara F. Terry, Alberto Riva, Chiara Viviani Anselmi, Alberto Malovini, Aya Kitamoto, Motoji Sawabe, Tomio Arai, Yasuyuki Gondo, Martin H. Steinberg, Nobuyoshi Hirose, Gil Atzmon, Gary Ruvkun, Clinton T. Baldwin, Thomas T. Perls,

RNA Research and Splicing

The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered.