Acromegaly Associated with Chiari-I Malformation and Polycystic Ovary Syndrome.
1996; The Japanese Society of Internal Medicine; Volume: 35; Issue: 10 Linguagem: Inglês
10.2169/internalmedicine.35.803
ISSN1349-7235
AutoresMasahiro Hara, Kazuo Ichikawa, Kesami Minemura, Hiroaki Kobayashi, Naomi Suzuki, Akihiro Sakurai, Yutaka Nishii, Kiyoshi Hashizume, Kuniyoshi Ohtsuka,
Tópico(s)Pituitary Gland Disorders and Treatments
ResumoWe report a 19-year-old female case of acromegaly associated with Chiari-I malformation and polycystic ovary syndrome. She also had syringomyelia and thoracic scoliosis. Although the association of acromegaly and Chiari-I malformation was by chance, exaggerated secretion of growth hormone may have aggravated the scoliosis. The incidence of polycystic ovary in acromegalic patients remains to be elucidated. However, elevation of plasma insulin and insulin-like growth factor, that is usually observed in patients with acromegaly, could stimulate androgen production in the ovaries. The patient was successfully treated with transsphenoidal adenomectomy for pituitary tumor and correction surgery for thoracic scoliosis.(Internal Medicine 35: 803-807, 1996)
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