Effects of Long-Term Thorotrast Exposure
1972; Radiological Society of North America; Volume: 103; Issue: 1 Linguagem: Inglês
10.1148/103.1.13
ISSN1527-1315
AutoresMurray L. Janower, Olli S. Miettinen, M. Jean Flynn,
Tópico(s)Acute Lymphoblastic Leukemia research
ResumoHomeRadiologyVol. 103, No. 1 PreviousNext Diagnostic RadiologyEffects of Long-Term Thorotrast ExposureMurray L. Janower22, Olli S. Miettinen, M. Jean FlynnMurray L. Janower22, Olli S. Miettinen, M. Jean FlynnAuthor Affiliations Massachusetts General HospitalBoston, Mass. 02114Murray L. Janower22Olli S. MiettinenM. Jean FlynnPublished Online:Apr 1 1972https://doi.org/10.1148/103.1.13MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In AbstractThe authors evaluated radiation-related morbidity in a follow-up study involving 724 patients who received Thorotrast for cerebral angiography and 315 control patients who underwent similar diagnostic examinations with use of nonradioactive media. Intensive clinical and laboratory examinations were conducted on 42 of the Thorotrast patients and 29 of the controls. In the Thorotrast series there were 2 cases of thorotrastoma, abnormalities in Brom-sulphalein and serum alkaline phosphatase values, a high frequency of chromosome aberrations, and 1 instance each of liver neoplasm, granulocytic leukemia, and nonalcoholic hepatic cirrhosis. Anemia, elevated white cell counts, and disturbances in red cell morphology were not found.Article HistoryAccepted: Nov 1971Published in print: Apr 1972 FiguresReferencesRelatedDetailsCited ByDesign and Applications of Nanoparticles in Biomedical ImagingSongping D.Huang2017Kontrastmittelretention in der Geschichte der RadiologieG.van Kaick, S.Delorme2016 | Der Radiologe, Vol. 56, No. 12History note: tragedy of ThorotrastShoichiTakekawa, YoshihikoUeda, YoshihiroHiramatsu, KihachiroKomiyama, HirotsuguMunechika2015 | Japanese Journal of Radiology, Vol. 33, No. 11Inorganic Nanoparticles Based Contrast Agents for X-ray Computed TomographyAnshumanJakhmola, NicolasAnton, Thierry F.Vandamme18 May 2012 | Advanced Healthcare Materials, Vol. 1, No. 4THOROTRAST-INDUCED PRIMARY CEREBRAL ANGIOSARCOMAGopalakrishnanBalamurali, Daniel G.du Plessis, MosesWengoy, NicholasBryan, AmitHerwadkar, Peter L.Richardson2009 | Neurosurgery, Vol. 65, No. 1Medical Devices of the Abdomen and Pelvis1Tim B. 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