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Sterol Precursors of Cholesterol in Adult Human Brain

1968; American Association for the Advancement of Science; Volume: 162; Issue: 3861 Linguagem: Inglês

10.1126/science.162.3861.1495

1095-9203

Giovanni Galli, E. Grossi Paoletti, Joseph F. Weiss,

Fatty Acid Research and Health

Adult human brain contains cholestanol and two series of cholesterol precursors having 30, 29, 28, and 27 carbon atoms; one has an unsaturated steroid nucleus, and the other is unsaturated in both nucleus and side chain. The ability of preparations of brain to incorporate a specific precursor into cholesterol, as well as into these sterol metabolites in vitro, indicates that cholesterol synthesis continues long after brain maturation ceases.