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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Bone marrow fibrosis (pseudo-myelofibrosis) in human kala-azar

2000; Brazilian Society of Tropical Medicine; Volume: 33; Issue: 4 Linguagem: Inglês

10.1590/s0037-86822000000400005

ISSN

1678-9849

Autores

Francisco Dário Rocha Filho, Francisco Valdeci de Almeida Ferreira, Flávia de Oliveira Mendes, Fernanda Nogueira Holanda Ferreira, Alexandre Karbage, Marília Lage Alencar, Danielle Clarisse Barbosa Costa,

Tópico(s)

Case Reports on Hematomas

Resumo

Thirty cases of human kala-azar were diagnosed by iliac crest biopsy and myeloculture. Histological analysis of 12 patients showed diffuse thickening of reticulin fibers. To the best of our knowledge, this is the third report describing secondary bone marrow fibrosis (myelofibrosis-like) associated with kala-azar. Patients with positive bone marrow fibrosis (pbmf = 12) were compared to patients without detectable bone marrow fibrosis (wbmf = 18). There were no significant differences in clinical and blood parameters following treatment. All patients showed regression of hepatosplenomegaly. Our findings suggest that associated bone marrow fibrosis is transient and did not interfere in the evolution of treated patients.

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