Upregulated miR‐106a plays an oncogenic role in pancreatic cancer
2014; Wiley; Volume: 588; Issue: 5 Linguagem: Inglês
10.1016/j.febslet.2014.01.007
ISSN1873-3468
AutoresPei Li, Qinhong Xu, Dong Zhang, Xuqi Li, Liang Han, Jianjun Lei, Wanxing Duan, Qingyong Ma, Zheng Wu, Zheng Wang,
Tópico(s)RNA modifications and cancer
ResumoCarcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. MicroRNAs control gene expression by negatively regulating protein‐coding mRNAs. Several reports demonstrated that miR‐106a is up‐regulated in gastric and colorectal cancers and promotes tumor progression. In contrast, in glioma miR‐106a plays the role of a tumor suppressor gene rather than an oncogene. Here we demonstrate that a high level of miR‐106a expression is present in pancreatic cancer. Furthermore, our investigation shows that miR‐106a has an oncogenic role in pancreatic tumorigenesis by promoting cancer cell proliferation, epithelial–mesenchymal transition and invasion by targeting tissue inhibitors of metalloproteinase 2 ( TIMP‐2 ). MiR‐106a could be a critical therapeutic target in pancreatic cancer.
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