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How Homologous Recombination Is Initiated

2004; Cell Press; Volume: 117; Issue: 2 Linguagem: Inglês

10.1016/s0092-8674(04)00338-1

1097-4172

Gerald R. Smith,

Plant Genetic and Mutation Studies

Views of how homologous recombination is initiated have changed over the past several decades: in the 1960s and 1970s, single-strand DNA lesions (nicks) were the leading contenders, but in the last decade, double-strand DNA breaks (DSBs) have reigned. In this issue of Cell, Lee et al. 2004Lee G.S Neiditch M.B Salus S.S Roth D.B Cell. 2004; 117 (, this issue): 171-184Abstract Full Text Full Text PDF PubMed Scopus (190) Google Scholar present evidence that nicks can stimulate homologous recombination and, in uncontrolled situations, may lead to translocations and other potentially dangerous genome rearrangements.