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Reduction of palmoplantar keratoderma Buschke–Fischer–Brauer locus to only 0.967Mb

2012; Elsevier BV; Volume: 67; Issue: 3 Linguagem: Inglês

10.1016/j.jdermsci.2012.06.011

1873-569X

Ons Mamaï, L. Boussofara, Labiba Adala, Abdelbasset Amara, Ilhem Ben Charfeddine, N. Ghariani, Badreddine Sriha, M. Denguezli, A. Mili, T. Belazreg, A. Saad, Judith Fischer, Moez Gribaa,

Contact Dermatitis and Allergies

Palmoplantar keratodermas are a family of dermatological diseases characterized by epidermal hyperkeratosis of the palms and soles [1]. Defects in different components of the desmosome and the keratin filaments have been described, and can be classified into three main categories according to the affected area of the palms and soles; diffuse, focal, and punctuate [2]. But many forms of the disease still have an unknown molecular basis [3]. Punctate palmoplantar keratoderma type I (PPK) (OMIM#148600), also called keratosis punctate palmoplantaris Buschke–Fischer–Brauer type was first described by Buschke and Fischer in 1910.