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EFFECT OF DIETARY LIPID ON UV LIGHT CARCINOGENESIS IN THE HAIRLESS MOUSE

1988; Wiley; Volume: 48; Issue: 5 Linguagem: Inglês

10.1111/j.1751-1097.1988.tb02882.x

1751-1097

Vivienne E. Reeve, M Matheson, Gavin E. Greenoak, Paul J. Canfield, Christa Boehm‐Wilcox, C. H. Gallagher,

Retinoids in leukemia and cellular processes

Abstract— Isocaloric feeding of diets varying in lipid content to albino hairless mice has shown that their susceptibility to skin tumorigenesis induced by simulated solar UV light was not affected by the level of polyunsaturated fat, 5% or 20%. However a qualitative effect of dietary lipid was demonstrated. Mice fed 20% saturated fat were almost completely protected from UV tumorigenesis when compared with mice fed 20% polyunsaturated fat. Multiple latent tumours were detected in the saturated fat‐fed mice by subsequent dietary replenishment, suggesting that a requirement for dietary unsaturated fat exists for the promotion stage of UV‐induced skin carcinogenesis.