Current Treatment of In-Stent Restenosis
2014; Elsevier BV; Volume: 63; Issue: 24 Linguagem: Inglês
10.1016/j.jacc.2014.02.545
ISSN1558-3597
AutoresFernándo Alfonso, Robert A. Byrne, Fernando Rivero, Adnan Kastrati,
Tópico(s)Cardiac Imaging and Diagnostics
ResumoManagement of patients with in-stent restenosis (ISR) remains an important clinical problem. Although drug-eluting stents (DES) have drastically reduced the incidence of ISR, treatment of DES-ISR is particularly challenging. ISR mainly results from aggressive neointimal proliferation, but recent data also suggest that neoatherosclerosis may play an important pathophysiological role. Intracoronary imaging provides unique insights to unravel the underlying substrate of ISR and may be used to guide repeated interventions. In this paper, we systematically reviewed clinical trial data with currently available therapeutic modalities, including DES and drug-coated balloons, in patients presenting with ISR within bare-metal stents or DES.
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