Role of the microenvironment in chronic lymphocytic leukaemia
2003; Wiley; Volume: 123; Issue: 3 Linguagem: Inglês
10.1046/j.1365-2141.2003.04679.x
ISSN1365-2141
Autores Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoBritish Journal of HaematologyVolume 123, Issue 3 p. 380-388 Role of the microenvironment in chronic lymphocytic leukaemia Federico Caligaris-Cappio, Federico Caligaris-Cappio Università Vita Salute San Raffaele, Milano, Italy. E-mail: [email protected]Search for more papers by this author Federico Caligaris-Cappio, Federico Caligaris-Cappio Università Vita Salute San Raffaele, Milano, Italy. E-mail: [email protected]Search for more papers by this author First published: 20 October 2003 https://doi.org/10.1046/j.1365-2141.2003.04679.xCitations: 141 Federico Caligaris-Cappio, MD, Istituto Scientifico San Raffaele, Via Olgettina 60, 20132 Milano, Italy. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Alfarano, A., Indraccolo, S., Circosta, P., Minuzzo, S., Vallario, A., Zamarchi, R., Fregonese, A., Calderazzo, F., Faldella, A., Aragno, M., Camaschella, C., Amadori, A. & Caligaris-Cappio, F. (1999) An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia. Blood, 93, 2327 – 2335. CASPubMedWeb of Science®Google Scholar Ambrosini, G., Adida, C. & Altieri, D.C. (1997) A novel anti-apoptosis gene, Survivin, expressed in cancer and lymphoma. Nature Medicine, 3, 917 – 921. 10.1038/nm0897-917 CASPubMedWeb of Science®Google Scholar Bergui, L., Gregoretti, M.G. & Caligaris-Cappio, F. (1994) Cyclosporin A in the treatment of B-chronic lymphocytic leukemia (B-CLL). Leukemia, 8, 1245 – 1246. CASPubMedWeb of Science®Google Scholar Buhmann, R., Nolte, A., Westhaus, D., Emmerich, B. & Hallek, M. (1999) CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells. Blood, 93, 1992 – 2002. 10.1182/blood.V93.6.1992.406k23_1992_2002 CASPubMedWeb of Science®Google Scholar Burger, J.A. & Kipps, T.J. (2002) Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukaemia B cells. Leukemia and Lymphoma, 43, 461 – 466. 10.1080/10428190290011921 CASPubMedWeb of Science®Google Scholar Burger, J.A., Burger, M. & Kipps, T.J. (1999) Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood, 94, 3658 – 3667. 10.1182/blood.V94.11.3658 CASPubMedWeb of Science®Google Scholar Burger, J.A., Tsukada, N., Burger, M., Zvaifler, N.J., Dell'Aquila, M. & Kipps, T.J. (2000) Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood, 96, 2655 – 2663. 10.1182/blood.V96.8.2655 CASPubMedWeb of Science®Google Scholar Buske, C., Gogowski, G., Schreiber, K., Rave-Frank, M., Hiddemann, W. & Wormann, B. (1997) Stimulation of B-chronic lymphocytic leukemia cells by murine fibroblasts, IL-4, anti-CD40 antibodies, and the soluble CD40 ligand. Experimental Hematology, 25, 329 – 337. CASPubMedWeb of Science®Google Scholar Caligaris-Cappio, F. (1996) B-chronic lymphocytic leukemia: a malignancy of anti-self B cells. Blood, 87, 2615 – 2620. CASPubMedWeb of Science®Google Scholar Caligaris-Cappio, F. (2001) How immunology is reshaping clinical disciplines: the example of haematology. Lancet, 358, 49 – 55. 10.1016/S0140-6736(00)05256-9 CASPubMedWeb of Science®Google Scholar Caligaris-Cappio, F. & Hamblin, T.J. (1999) B-cell chronic lymphocytic leukemia: a bird of a different feather. Journal of Clinical Oncology, 17, 399 – 408. 10.1200/JCO.1999.17.1.399 CASPubMedWeb of Science®Google Scholar Caligaris-Cappio, F., Bergui, L., Tesio, L. , Corbascio, G., Tousco, F. & Marchisio, P.C. (1986) Cytoskeleton organization is aberrantly rearranged in the cells of B-chronic lymphocytic leukemia and hairy cell leukemia. Blood, 67, 233 – 239. PubMedWeb of Science®Google Scholar Carbone, A., Gloghini, A., Gruss, H.J. & Pinto, A. (1995) CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease. American Journal of Pathology, 147, 912 – 922. CASPubMedWeb of Science®Google Scholar Chen, H., Treweeke, A.T., West, D.C., Till, K.J., Cawley, J.C., Zuzel, M. & Toh, C.H. (2000) In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells. Blood, 96, 3181 – 3187. 10.1182/blood.V96.9.3181.h8003181_3181_3187 CASPubMedWeb of Science®Google Scholar Chilosi, M., Pizzolo, G., Caligaris-Cappio, F., Ambrosetti, A., Morittu, L., Bonetti, F., Fiore-Donati, L. & Janossy, G. (1985) Immunohistochemical demonstration of follicular dendritic cells in bone marrow involvement of B-cell chronic lymphocytic leukemia. Cancer, 56, 328 – 332. 10.1002/1097-0142(19850715)56:2 3.0.CO;2-Q PubMedWeb of Science®Google Scholar Chiorazzi, N. & Ferrarini, M. (2003) B cell chronic lymphocytic leukaemia: lessons learned from studies of the B cell antigen receptor. Annual Review of Immunology, 21, 841 – 894. 10.1146/annurev.immunol.21.120601.141018 CASPubMedWeb of Science®Google Scholar Cossman, J., Messineo, C. & Bagg, A. (1998) Reed-Sternberg cell: survival in a hostile sea. Laboratory Investigation, 78, 229 – 235. CASPubMedWeb of Science®Google Scholar Cragg, M.S., Chan, T.C., Fox, M.D., Tutt, A., Smith, A., Oscier, D.G., Hamblin, T.J. & Glennie, M.J. (2002) The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signalling for apoptosis. Blood, 100, 3068 – 3076. 10.1182/blood.V100.9.3068 CASPubMedWeb of Science®Google Scholar Damle, R.N., Wasil, T., Fais, F., Ghiotto, F., Valetto, A., Allen, S.L., Buchbinder, A., Budman, D., Dittmar, K., Kolitz, J., Lichtman, S.M., Schulman, P., Vinciguerra, V.P., Rai, K.R., Ferrarini, M. & Chiorazzi, N. (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood, 94, 1840 – 1847. 10.1182/blood.V94.6.1840 CASPubMedWeb of Science®Google Scholar Damle, R.N., Ghiotto, F., Valetto, A., Albesiano, E., Fais, F., Yan, X.J., Sison, C.P., Allen, S.L., Kolitz, J., Schulman, P., Vinciguerra, V.P., Budde, P., Frey, J., Rai, K.R., Ferrarini, M. & Chiorazzi, N. (2002) B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood, 99, 4087 – 4093. 10.1182/blood.V99.11.4087 CASPubMedWeb of Science®Google Scholar De Rossi, G., Zarcone, D., Mauro, F., Cerruti, G., Tenca, C., Puccetti, A., Mandelli, F. & Grossi, C.E. (1993) Adhesion molecule expression on B-cell chronic lymphocytic leukemia cells: malignant cell phenotypes define distinct disease subsets. Blood, 81, 2679 – 2687. PubMedWeb of Science®Google Scholar Decker, T., Hipp, S., Ringshausen, I., Bogner, C., Oelsner, M., Schneller, F. & Peschel, C. (2003) Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and Survivin. Blood, 101, 278 – 285. 10.1182/blood-2002-01-0189 CASPubMedWeb of Science®Google Scholar Dhodapkar, M.V., Geller, M.D., Chang, D.H., Shimizu, K., Fujii, S., Dhodapkar, K.M. & Krasovsky, J. (2003) A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. Journal of Experimental Medicine, 197, 1667 – 1676. 10.1084/jem.20021650 CASPubMedWeb of Science®Google Scholar Dohner, H., Stilgenbauer, S., Benner, A., Leupolt, E., Krober, A., Bullinger, L., Dohner, K., Bentz, M. & Lichter, P. (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. New England Journal of Medicine, 343, 1910 – 1916. 10.1056/NEJM200012283432602 CASPubMedWeb of Science®Google Scholar Dorshkind, K. (1990) Regulation of hemopoiesis by bone marrow stromal cells and their products. Annual Review of Immunology, 8, 111 – 137. 10.1146/annurev.iy.08.040190.000551 CASPubMedWeb of Science®Google Scholar Fluckiger, A.C., Rossi, J.F., Bussel, A. , Bryon, P., Banchereau, J. & Defrance, T. (1992) Responsiveness of chronic lymphocytic leukemia B cells activated via surface Igs or CD40 to B-cell tropic factors. Blood, 80, 3173 – 3181. 10.1182/blood.V80.12.3173.3173 CASPubMedWeb of Science®Google Scholar Ghia, P. & Caligaris-Cappio, F. (2000) The non-dispensable role of microenvironment in the natural history of low grade neoplasms. Advances in Cancer Research, 79, 157 – 173. 10.1016/S0065-230X(00)79005-1 CASPubMedWeb of Science®Google Scholar Ghia, P., Granziero, L., Chilosi, M. & Caligaris-Cappio, F. (2002a) Chronic B cell malignancies and bone marrow microenvironment. Seminars in Cancer Biology, 12, 149 – 155. 10.1006/scbi.2001.0423 PubMedWeb of Science®Google Scholar Ghia, P., Strola, G., Granziero, L., Geuna, M., Guida, G., Sallusto, F., Ruffing, N., Montagna, L., Piccoli, P., Chilosi, M. & Caligaris-Cappio, F. (2002b) Chronic Lymphocytic Leukemia B Cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22. European Journal of Immunology, 32, 1403 – 1413. 10.1002/1521-4141(200205)32:5 3.0.CO;2-Y CASPubMedWeb of Science®Google Scholar Granziero, L., Ghia, P., Circosta, P., Gottardi, D., Strola, G., Geuna, M., Montagna, L., Piccoli, P., Chilosi, M. & Caligaris-Cappio, F. (2001) Survivin is expressed upon CD40 stimulation and interfaces proliferation and apoptosis in B-chronic lymphocytic leukemia. Blood, 97, 2777 – 2783. 10.1182/blood.V97.9.2777 CASPubMedWeb of Science®Google Scholar Granziero, L., Circosta, P., Scielzo, C., Frisaldi, E., Stella, S., Geuna, M., Giordano, S., Ghia, P. & Caligaris-Cappio, F. (2003) CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes. Blood, 101, 1962 – 1969. 10.1182/blood-2002-05-1339 CASPubMedWeb of Science®Google Scholar Grewal, I.S. & Flavell, R.A. (1998) CD40 and CD154 in cell-mediated immunity. Annual Review of Immunology, 16, 111 – 135. 10.1146/annurev.immunol.16.1.111 CASPubMedWeb of Science®Google Scholar Hamblin, T.J., Davis, Z., Gardiner, A., Oscier, D.G. & Stevenson, F.K. (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood, 94, 1848 – 1854. 10.1182/blood.V94.6.1848 CASPubMedWeb of Science®Google Scholar Hashimoto, S., Chiorazzi, N. & Gregersen, P.K. (1995) Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. Molecular Immunology, 32, 651 – 659. 10.1016/0161-5890(95)00023-8 CASPubMedWeb of Science®Google Scholar Houlston, R.S., Catovsky, D. & Yuille, M.R. (2002) Genetic susceptibility to chronic lymphocytic leukemia. Leukemia, 16, 1008 – 1014. 10.1038/sj.leu.2402538 CASPubMedWeb of Science®Google Scholar Indraccolo, S., Minuzzo, S., Zamarchi, R., Calderazzo, F., Piovan, E. & Amadori, A. (2002) Alternative spliced forms of Igα and Igβ prevent B cell receptor expression on the cell surface. European Journal of Immunology, 32, 1530 – 1540. 10.1002/1521-4141(200206)32:6 3.0.CO;2-# PubMedWeb of Science®Google Scholar Jones, D., Benjamin, R.J., Shahsafaei, A. & Dorfman, D.M. (2000) The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood, 95, 627 – 632. 10.1182/blood.V95.2.627 CASPubMedWeb of Science®Google Scholar Kato, K., Cantwell, M.J., Sharma, S. & Kipps, T.J. (1998) Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells. Journal of Clinical Investigation, 101, 1133 – 1141. 10.1172/JCI1472 CASPubMedWeb of Science®Google Scholar Keely, P., Parise, L. & Juliano, R. (1998) Integrins and GTPases in tumour cell growth, mobility and invasion. Trends in Cell Biology, 8, 101 – 106. 10.1016/S0962-8924(97)01219-1 CASPubMedWeb of Science®Google Scholar Kitada, S., Zapata, J.M., Andreeff, M. & Reed, J.C. (1999) Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia. British Journal of Haematology, 106, 995 – 1004. 10.1046/j.1365-2141.1999.01642.x CASPubMedWeb of Science®Google Scholar Klein, U., Tu, Y., Stolovitzky, G.A., Mattioli, M., Cattoretti, G., Husson, H., Freedman, A., Inghirami, G., Cro, L., Baldini, L., Neri, A., Califano, A. & Dalla Favera, R. (2001) Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. Journal of Experimental Medicine, 194, 1625 – 1638. 10.1084/jem.194.11.1625 CASPubMedWeb of Science®Google Scholar Korz, C., Pscherer, A., Benner, A., Mertens, D., Schaffner, C., Leupolt, E., Dohner, H., Stilgenbauer, S. & Lichter, P. (2002) Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. Blood, 99, 4554 – 4561. 10.1182/blood.V99.12.4554 CASPubMedWeb of Science®Google Scholar Koyama, M., Nakamura, T., Higashihara, M., Herren, B., Kuwata, S., Shibata, Y., Okumura, K. & Kurokawa, K. (1995) The novel variants of mb-1 and B29 transcripts generated by alternative mRNA splicing. Immunology Letters, 47, 151 – 156. 10.1016/0165-2478(95)00071-X CASPubMedWeb of Science®Google Scholar Kuppers, R., Klein, U., Hansmann, M.L. & Rajewsky, K. (1999) Cellular origin of human B-cell lymphomas. New England Journal of Medicine, 341, 1520 – 1529. 10.1056/NEJM199911113412007 CASPubMedWeb of Science®Google Scholar Lagneaux, L., Delforge, A., Bron, D., De Bruyn, C. & Stryckmans, P. (1998) Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood, 91, 2387 – 2396. 10.1182/blood.V91.7.2387 CASPubMedWeb of Science®Google Scholar Lampert, I.A., Wotherspoon, A., Van Noorden, S. & Hasserjian, R.P. (1999) High expression of CD23 in the proliferation centers of chronic lymphocytic leukemia in lymph nodes and spleen. Human Pathology, 30, 648 – 654. 10.1016/S0046-8177(99)90089-8 CASPubMedWeb of Science®Google Scholar Lanham, S., Hamblin, T., Oscier, D., Ibbotson, R., Stevenson, F. & Packham, G. (2003) Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia. Blood, 101, 1087 – 1093. 10.1182/blood-2002-06-1822 CASPubMedWeb of Science®Google Scholar Lennert, K., Mohri, N., Stein, H., Kaiserling, E. & Muller-Hermelink, H.K. (1978) Malignant Lymphomas Other than Hodgkin's Disease, pp. 119 – 129. Springer-Verlag, Berlin, Heidelberg, New York. 10.1007/978-3-642-81092-3 Google Scholar Li, F., Ambrosini, G., Chu, E.Y., Plescia, J., Tognin, S., Marchisio, P.C. & Altieri, D.C. (1998) Control of apoptosis and mitotic spindle checkpoint by Survivin. Nature, 396, 580 – 584. 10.1038/25141 CASPubMedWeb of Science®Google Scholar Liu, Y.J., Joshua, D.E., Williams, G.T., Smith, C.A., Gordon, J. & MacLennan, I.C. (1989) Mechanism of antigen-driven selection in germinal centres. Nature, 342, 929 – 931. 10.1038/342929a0 CASPubMedWeb of Science®Google Scholar Ma, Q., Jones, D. & Springer, T.A. (1999) The chemokine receptor CXCR4 is required for the retention of of B lineage and granulocytic precursors within the bone marrow microenvironment. Immunity, 10, 463 – 471. 10.1016/S1074-7613(00)80046-1 CASPubMedWeb of Science®Google Scholar Mason, D.Y., van Noesel, C.J., Cordell, J.L., Comans-Bitter, W.M., Micklem, K., Tse, A., van Lier, R.A. & van Dongen, J.J. (1992) The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation. European Journal of Immunology, 22, 2753 – 2758. 10.1002/eji.1830221044 CASPubMedWeb of Science®Google Scholar Mohle, R., Failenschmid, C., Bautz, F. & Kanz, L. (1999) Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is asociated with increased functional response to stromal-cell derived factor-1 (SDF-1). Leukemia, 13, 1954 – 1959. 10.1038/sj.leu.2401602 CASPubMedWeb of Science®Google Scholar Molica, S., Vacca, A., Ribatti, D., Cuneo, A., Cavazzini, F., Levato, D., Vitelli, G., Tucci, L., Roccaro, A.M. & Dammacco, F. (2002) Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia. Blood, 100, 3344 – 3351. 10.1182/blood-2002-01-0084 CASPubMedWeb of Science®Google Scholar Nagasawa, T., Kikutani, H. & Kishimoto, T. (1994) Molecular cloning and structure of a pre-B cell growth-stimulating factor. Proceedings of the National Academiy of Sciences of the United States of America, 91, 2305 – 2309. 10.1073/pnas.91.6.2305 CASPubMedWeb of Science®Google Scholar Panayiotidis, P., Jones, D., Ganeshaguru, K., Foroni, L. & Hoffbrand, A.V. (1996) Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. British Journal of Haematology, 92, 97 – 103. 10.1046/j.1365-2141.1996.00305.x CASPubMedWeb of Science®Google Scholar Payelle-Brogard, B., Magnac, C., Mauro, F.R., Mandelli, F. & Dighiero, G. (1999) Analysis of the B-cell receptor B29 (CD79b) gene in familial chronic lymphocytic leukemia. Blood, 94, 3516 – 3522. CASPubMedWeb of Science®Google Scholar Pedersen, I.M., Kitada, S., Leoni, L.M., Zapata, J.M., Karras, J.G., Tsukada, N., Kipps, T.J., Chois, Y.S., Bennett, F. & Reed, J.C. (2002) Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1. Blood, 100, 1795 – 1801. 10.1182/blood-2002-04-1174 CASPubMedWeb of Science®Google Scholar Petrasch, S., Stein, H., Kosco, M.H. & Brittinger, G. (1991) Follicular dendritic cells in non-Hodgkin lymphomas: localisation, characterisation and pathophysiological aspects. European Journal of Cancer, 27, 1052 – 1056. 10.1016/0277-5379(91)90280-Q CASPubMedWeb of Science®Google Scholar Pileri, S.A., Ascani, S., Sabattini, E., Fraternali-Orcioni, G., Poggi, S., Piccioli, M., Piccaluga, P.P., Gamberi, B., Zinzani, P.L., Leoncini, L. & Falini, B. (2000) The pathologist's view point. Part I – indolent lymphomas. Haematologica, 85, 1291 – 1307. CASPubMedWeb of Science®Google Scholar Pistoia, V. (1997) Production of cytokines by human B cells in health and disease. Immunology Today, 18, 343 – 350. 10.1016/S0167-5699(97)01080-3 CASPubMedWeb of Science®Google Scholar Pizzolo, G., Chilosi, M., Ambrosetti, A., Semenzato, G., Fiore-Donati, L. & Perona, G. (1983) Immunohistologic study of bone marrow involvement in B-chronic lymphocytic leukemia. Blood, 62, 1289 – 1296. 10.1182/blood.V62.6.1289.1289 CASPubMedWeb of Science®Google Scholar Reed, J.C. (2001) The Survivin saga goes in vivo. Journal of Clinical Investigation, 108, 965 – 969. 10.1172/JCI14123 CASPubMedWeb of Science®Google Scholar Rezvany, M.R., Jeddi-Tehrani, M., Wigzell, H., Osterborg, A. & Mellstedt, H. (2003) Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia. Blood, 101, 1063 – 1070. 10.1182/blood-2002-03-0746 CASPubMedWeb of Science®Google Scholar Rosenwald, A., Alizadeh, A.A., Widhopf, G., Simon, R., Davis, R.E., Yu, X., Yang, L., Pickeral, O.K., Rassenti, L.Z,. Powell, J., Botstein, D., Byrd, J.C., Grever, M.R., Cheson, B.D., Chiorazzi, N., Wilson, W.H., Kipps, T.J., Brown, P.O. & Staudt, L.M. (2001) Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. Journal of Experimental Medicine, 194, 1639 – 1647. 10.1084/jem.194.11.1639 CASPubMedWeb of Science®Google Scholar Rozman, C. & Montserrat, E. (1995) Chronic lymphocytic leukemia. New England Journal of Medicine, 333, 1052 – 1057. 10.1056/NEJM199510193331606 CASPubMedWeb of Science®Google Scholar Schmid, C. & Isaacson, P.G. (1994) Proliferation centers in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study. Histopathology, 24, 445 – 451. 10.1111/j.1365-2559.1994.tb00553.x PubMedWeb of Science®Google Scholar Schmidt, S.M., Schag, K., Muller, M.R., Weck, M.M., Appel, S., Kanz, L., Grunebach, F. & Brossart, P. (2003) Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells. Blood, 102, 571 – 576. 10.1182/blood-2002-08-2554 CASPubMedWeb of Science®Google Scholar Schroeder, Jr, H.W. & Dighiero, G. (1994) The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunology Today, 15, 288 – 294. 10.1016/0167-5699(94)90009-4 CASPubMedWeb of Science®Google Scholar Serrano, D., Monteiro, J., Allen, S.L., Kolits, J., Schulman, P., Lichtman, S.M., Buchbinder, A., Vinciguerra, V.P., Chiorazzi, N. & Gregerson, P.K. (1997) Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. Journal of Immunology, 158, 1482 – 1489. CASPubMedWeb of Science®Google Scholar Stein, H., Gerdes, J. & Mason, D.Y. (1982) The normal and malignant germinal centre. Clinics in Haematology, 11, 531 – 559. PubMedWeb of Science®Google Scholar Stevenson, F.K., Sahota, S.S., Ottensmeier, C.H., Zhu, D., Forconi, F. & Hamblin, T.J. (2001) The occurrence and significance of V gene mutations in B cell-derived human malignancy. Advances in Cancer Research, 83, 81 – 116. 10.1016/S0065-230X(01)83004-9 CASPubMedWeb of Science®Google Scholar Trentin, L., Agostini, C., Facco, M., Piazza, F., Perin, A., Siviero, M., Guerrieri, C., Galvan, S., Adami, F., Zambello, R. & Semenzato, G. (1999) The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis. Journal of Clinical Investigation, 104, 115 – 121. 10.1172/JCI7335 CASPubMedWeb of Science®Google Scholar Vincent, A.M., Cawley, J.C. & Burthem, J. (1996) Integrin function in chronic lymphocytic leukemia. Blood, 87, 4780 – 4788. 10.1182/blood.V87.11.4780.bloodjournal87114780 CASPubMedWeb of Science®Google Scholar Wickremasinghe, R.G. & Hoffbrand, A.V. (1999) Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies. Blood, 93, 3587 – 3600. CASPubMedWeb of Science®Google Scholar Wierda, W.G., Cantwell, M.J., Woods, S.J., Rassenti, L.Z,. Prussak, C.E. & Kipps, T.J. (2000) CD40-ligand (CD154) gene therapy for chronic lymphocytic leukemia. Blood, 96, 2917 – 2924. 10.1182/blood.V96.9.2917 CASPubMedWeb of Science®Google Scholar William, J., Euler, C., Christensen, S. & Shlomnchik, M.J. (2002) Evolution of autoantibody responses via somatic hypermutations outside of germinal centers. Science, 297, 2006 – 2008. 10.1126/science.1073924 PubMedWeb of Science®Google Scholar Zomas, A.P., Matutes, E., Morilla, R., Owusu-Ankomah, K., Seon, B.K. & Catovsky, D. (1996) Expression of the immunoglobulin-associated protein B29 in B cell disorders with the monoclonal antibody SN8 (CD79b). Leukemia, 10, 1966 – 1970. PubMedWeb of Science®Google Scholar Zupo, S., Massara, R., Dono, M., Rossi, E., Malavasi, F., Cosulich, E. & Ferrarini, M. (2000) Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD. Blood, 95, 1199 – 1206. CASPubMedWeb of Science®Google Scholar Citing Literature Volume123, Issue3November 2003Pages 380-388 ReferencesRelatedInformation
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