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Predicting protein function from sequence and structural data

2005; Elsevier BV; Volume: 15; Issue: 3 Linguagem: Inglês

10.1016/j.sbi.2005.04.003

1879-033X

James D. Watson, Roman A. Laskowski, Janet M. Thornton,

Biomedical Text Mining and Ontologies

When a protein's function cannot be experimentally determined, it can often be inferred from sequence similarity. Should this process fail, analysis of the protein structure can provide functional clues or confirm tentative functional assignments inferred from the sequence. Many structure-based approaches exist (e.g. fold similarity, three-dimensional templates), but as no single method can be expected to be successful in all cases, a more prudent approach involves combining multiple methods. Several automated servers that integrate evidence from multiple sources have been released this year and particular improvements have been seen with methods utilizing the Gene Ontology functional annotation schema.