Preliminary Results of the Combination of Bevacizumab and Weekly Paclitaxel in Advanced Melanoma
2008; Karger Publishers; Volume: 74; Issue: 1-2 Linguagem: Inglês
10.1159/000138351
ISSN1423-0232
AutoresMaría González‐Cao, Santiago Viteri, Ángel Díaz‐Lagares, A. González, Pedro Redondo, Yago Nieto, J. Espinós, Á. Chopitea, Mariano Ponz‐Sarvisé, Salvador Martín‐Algarra,
Tópico(s)Cutaneous Melanoma Detection and Management
ResumoPretreated advanced melanoma is a poor prognosis scenario with few, if any, active therapeutic options. The antibody against vascular endothelial growth factor, bevacizumab, has demonstrated increased activity in combination with chemotherapy in many tumors. We intended to evaluate the activity of the combination of weekly paclitaxel and bevacizumab in previously treated metastatic melanoma.Patients with previously treated metastatic melanoma received paclitaxel 70 mg/m(2) weekly and bevacizumab 10 mg/kg biweekly for 5 consecutive weeks every 6 weeks.Twelve patients were treated. Two patients (16.6%) achieved a partial response and 7 patients (58.3%) stable disease. Responses were seen in soft tissue, lung and brain metastases. Median disease-free and overall survival times were 3.7 and 7.8 months, respectively. Treatment was well tolerated. Main toxicities were grade 3 asymptomatic lymphopenia in 6 patients, grade 3 leucopenia in 2 patients, and grade 3 thrombocytopenia in 1 patient.Our preliminary results suggest that the combination of bevacizumab and weekly paclitaxel is active and safe in patients with metastatic melanoma, warranting further investigation.
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