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Increased antibodies for the α7 subunit of the nicotinic receptor in schizophrenia

2009; Elsevier BV; Volume: 109; Issue: 1-3 Linguagem: Inglês

10.1016/j.schres.2009.01.023

1573-2509

Michelle J. Chandley, Merry N. Miller, Christine Newell Kwasigroch, Tracy D. Wilson, Barney E. Miller,

Receptor Mechanisms and Signaling

One of the etiological theories of schizophrenia is dysregulation of the immune system. Autoantibodies specific for the α7 subunit of the nicotinic receptor could potentially contribute to the pathophysiology of the disease. In this study, positive antibodies specific for the receptor were found to exist in 23% of the patients diagnosed with schizophrenia (n = 21). On the average, levels for the antibody were elevated in the schizophrenia patient population than in controls. The data also suggests that there is a significant correlation between antibody titer and age, lending support to the neurodegenerative nature of the disease.