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" SELF " AND " NOT-SELF " IN IMMUNOLOGY

1974; Elsevier BV; Volume: 303; Issue: 7870 Linguagem: Inglês

10.1016/s0140-6736(74)90685-0

1474-547X

P Grabar,

Immunodeficiency and Autoimmune Disorders

If, instead of the classical assumption that immunological phenomena are based on defence mechanisms, it is assumed that they are derived from the physiological system of nutrition and involve the transport of catabolic and metabolic substances, and the "cleaning up" of residual products, this same mechanism can be envisaged as acting as a defence against foreign substances. No further complicated ad-hoc hypotheses are then required to explain immunological phenomena such as recognition of " self ", autoantibody formation, and, possibly, tolerance.