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Chemistry and biology of novel amine fungicides: Attempts to improve the antifungal activity of fenpropimorph

1991; Wiley; Volume: 31; Issue: 4 Linguagem: Inglês

10.1002/ps.2780310407

1096-9063

Alan Akers, E. Ammermann, Ernst Buschmann, Norbert Götz, Walter Himmele, Lorenz Gisela, Ernst‐Heinrich Pommer, Costin N. Rentzea, Franz Röhl, Hardo Siegel, Bernhard Zipperer, Hubert Sauter, Matthias Zipplies,

Pesticide and Herbicide Environmental Studies

Abstract In spite of considerable efforts by many workers, there has been a lack of progress in the area of amine fungicides since fenpropimorph. Random synthesis of a large variety of different amine compounds, as well as intelligent structural modification of the lead structure fenpropimorph (well over 15 000 amines have been screened at BASF alone) have not led to a new market product so far. Further work has been focused on the reported mode of action of fenpropimorph, notably on the inhibition of the sterol Δ 14 ‐reductase. Although some doubt has to be cast on the hypothesis that fenpropimorph behaves as a sterol mimic, the concept of ‘high energy intermediate’ inhibitors has been employed successfully. Rational drug design of azasterol mimics has led to a number of very potent inhibitors of the sterol Δ 14 ‐reductase which also displayed high fungicidal activity in the greenhouse. Although many of these compounds are more powerful reductase inhibitors than fenpropimorph, under field conditions none showed significant advantages over this established fungicide. Most likely, fenpropimorph already exhibits the maximum fungicidal activity which can be attained by blocking the sterol Δ 14 ‐reductase. This would mean that, with the development of the ‘second generation’ amine fungicide fenpropimorph, this class of compounds has already virtually been optimized.