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BIBTEX RIS

A bioactive film based on cashew gum polysaccharide for wound dressing applications

2015; Elsevier BV; Volume: 122; Linguagem: Inglês

10.1016/j.carbpol.2014.12.067

1879-1344

Bruna Rodrigues Moreira, Karla de Aleluia Batista, Elisandra Gava de Castro, Eliana Martins Lima, Kátia Flávia Fernandes,

Polysaccharides Composition and Applications

This work presents the development of a new bioactive material for wound therapeutics which may play a dual role of modulate metallo proteinases activity while prevents infection blocking out pathogenic microorganisms and foreign materials. A CGP/PVA film was activated by covalent immobilization of trypsin. Results from biocompatibility test revealed that PDL fibroblasts grown on the surface of CGP/PVA and the high amount of viable cells proved absence of cytotoxicity. Trypsin immobilized onto CGP/PVA film remained 100% active after 28 days stored dried at room temperature. In addition, CGP/PVA-trypsin film could be used for 9 cycles of storage/use without loss of activity. After immobilization, trypsin retained its collagenolytic activity, indicating this material as a promising material for wound dressing applications.