Replacement of Liver Function in Rats by Transplantation of Microcarrier-Attached Hepatocytes
1986; American Association for the Advancement of Science; Volume: 233; Issue: 4769 Linguagem: Inglês
10.1126/science.2426782
ISSN1095-9203
AutoresAchilles A. Demetriou, James F. Whiting, David Feldman, Stanley Μ. Levenson, Namita Roy Chowdhury, Albert D. Moscioni, Michael Kram, Jayanta Roy Chowdhury,
Tópico(s)Liver physiology and pathology
ResumoIsolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated dextran microcarriers and transplanted by intraperitoneal injection into rats. Survival and function of the transplanted hepatocytes have been demonstrated in mutant rats lacking bilirubin-uridine diphosphate glucuronosyltransferase activity (Gunn strain) and rats with inherited lack of plasma albumin (Nagase analbuminemia rat strain). This simple technique promises to be useful in the treatment of acute liver failure in humans.
Referência(s)