Portal de Periódicos da CAPES

A New Sequential Intramolecular Cyclization Based on the Boekelheide Rearrangement

2010; Wiley; Volume: 2011; Issue: 2 Linguagem: Inglês

10.1002/ejoc.201000936

1434-193X

Assunta Massaro, Alessandro Mordini, Anna Mingardi, Jens Klein, Daniele Andreotti,

Cyclopropane Reaction Mechanisms

Abstract Pyrrolidines and piperidines were synthesized from (aminoalkyl)pyridine N ‐oxides with a general and quite efficient method developed by using di‐ tert ‐butylsilyl bis(trifluoromethanesulfonate) as a new promoter for a Boekelheide‐type reaction. The use of a new Boekelheide promoter, which is compatible with amino groups, opens new perspectives in view of its application in intramolecular cyclizations.