The multiple basal-cell nevi syndrome.An analysis of a syndrome consisting of multiple nevoid basal-cell carcinoma, jaw cysts, skeletal anomalies, medulloblastoma, and hyporesponsiveness to parathormone
1965; Wiley; Volume: 18; Issue: 1 Linguagem: Inglês
10.1002/1097-0142(196501)18
ISSN1097-0142
AutoresRobert J. Gorlin, Robert A. Vickers, Elmer E. Kelln, John J. Williamson,
Tópico(s)Oral and Maxillofacial Pathology
ResumoCancerVolume 18, Issue 1 p. 89-104 ArticleFree Access The multiple basal-cell nevi syndrome. An analysis of a syndrome consisting of multiple nevoid basal-cell carcinoma, jaw cysts, skeletal anomalies, medulloblastoma, and hyporesponsiveness to parathormone Robert J. Gorlin D.D.S., M.S., Robert J. Gorlin D.D.S., M.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this authorRobert A. Vickers D.D.S., M.S., Robert A. Vickers D.D.S., M.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this authorElmer Kelln D.D.S., M.S., Elmer Kelln D.D.S., M.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this authorJohn J. Williamson M.D.SC., F.D.S.R.C.S., John J. Williamson M.D.SC., F.D.S.R.C.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this author Robert J. Gorlin D.D.S., M.S., Robert J. Gorlin D.D.S., M.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this authorRobert A. Vickers D.D.S., M.S., Robert A. Vickers D.D.S., M.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this authorElmer Kelln D.D.S., M.S., Elmer Kelln D.D.S., M.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this authorJohn J. Williamson M.D.SC., F.D.S.R.C.S., John J. Williamson M.D.SC., F.D.S.R.C.S. Division of Oral Pathology, School of Dentistry, University of Minnesota, Minneapolis 14, Minn. Department of Oral Pathology, School of Dentistry, University of West Virginia, Morgantown, W. Va. Department of Dentistry, University of Western Australia, Perth, AustraliaSearch for more papers by this author First published: January 1965 https://doi.org/10.1002/1097-0142(196501)18:1 3.0.CO;2-9Citations: 161AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Allington, H. V.: Benign cystic epithelioma. [Abstr.] A. M. A. Arch. Dermat. 80: 505–506, 1959. 2 Anderson, D. E.; McClendon, J. L., and Howell, J. B.: Genetics and skin tumors, with special reference to basal cell nevi. In Tumors of the Skin; a Collection of Papers Presented at the Seventh Annual Clinical Conference on Cancer, 1962, at The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas. Chicago, Ill. Year Book Medical Publishers, Inc. 1964; pp. 91–127. 3 Ashbury, H. E.; Whildin, J. G., and Rogers, F. T.: Roentgenological reports of chest examinations made of registrants at U. S. Army Induction Station No. 6, Third Corps Area, Baltimore, Md., May 1, 1941 to March 31, 1942. Am. J. Roentgenol. 48: 347–351, 1942. 4 Bennett, P. H.: Multiple dentigerous cysts; report of case. J. Am. Dent. A. 24: 894–898, 1937. 5 Beyrent, J. R.: Multiple dentigerous cysts in 4 members of 1 family. J. Am. Dent. A. 25: 623–625, 1938. 6 Beyrent, J. R.: Personal communication, 1963. 7 Bigelow, H. M.: Hereditary cysts. J. Am. Dent. A. 36: 360–363, 1948. 8 Binkley, G. W., and Johnson, H. H., Jr.: Epithelioma adenoides cysticum; basal cell nevi, agenesis of corpus callosum and dental cysts. A. M. A. Arch. Dermat. & Syph. 63: 73–84, 1951. 9 Bloch-Jørgensen, K.: Die sogenannten follikulären Zysten. Vrtljschr. Zahnh. 44: 301–304, 1928. 10 Block, J. B., and Clendenning, W. E.: Parathyroid hormone hyporesponsiveness in patients with basal-cell nevi and bone defects. New England J. Med. 268: 1157–1162, 1963. 11 Boyer, B. E., and Martin, M. M.: Marfan's syndrome; report of case manifesting giant bone of cyst of mandible and multiple (110) basal cell carcinomata. Plast & Reconstruct. Surg. 22: 257–263, 1958. 12 Boyko, G. V.; Surgent, J. W., and Mohnac, A. M.: Bilateral dentigerous cyst of mandible; report of case and discussion of follicular cysts. J. Am. Dent. A. 28: 1226–1229, 1941. 13 Caldwell, J. B., and Thompson, H. C.: Bilateral multilocular follicular cysts of maxilla and mandible. J. Oral Surg. 13: 102–107, 1955. 14 Calnan, C. D.: Two cases of multiple naevoid basal cell epitheliomata? Porokeratosis of Mantoux. Brit. J. Dermat. 65: 219–221, 1953. 15 Carney, R. G.: Linear unilateral basal-cell nevus with comedones; report of case A. M. A. Arch. Dermat. & Syph. 65: 471–476, 1952. 16 Catania, A. F.: Report and comment on unusual case of multiple follicular cysts with recurrence. Oral Surg. 5: 895–906, 1952. 17 Clarkson, P., and Wilson, H.: Two cases of basal-cell congenital nævus. Proc. Roy. Soc. Med. 53: 295–296, 1960. 18 Cook, W. A.: Personal communication, 1963. 19 Davidson, F.: Multiple naevoid basal cell carcinomata and associated congenital abnormalities. Brit. J. Dermat. 74: 439–444, 1962. 20 Dechaume, M.; Grellet, M.; Payen, J.; Bonneau, M., and Marie, M.: Dysembryoplasies épidermiques des maxillaires; kystes avec dents vivantes; kystes épidermoïdes; cholestéatomes. Rev. Stomatol. 59: 185–210, 1958. 21 Dillon, C.: Case of multiple maxillary cysts with ocular complications. Brit. Dent. J. 71: 209–213, 1941. 22 Droege, F.: Multiple Zahnzysten oder polyzystisches Adamantinom? Stoma 5: 187–191, 1952. 23 Einfeldt, H.: Beleuchtung des Erbfaktors durch Familienanamnese. Deutsche zahnärztl. Ztschr. 16: 899–904, 1961. 24 Eisenbud, L.; Brooks, H., and Busch, S.: Klippel-Feil syndrome with multiple cysts of jawbones. Oral Surg. 5: 659–666, 1952. 25 Epstein, W., and Kligman, A. M.: Pathogenesis of milia and benign tumors of skin. J. Invest. Dermat. 26: 1–11, 1956. 26 Etter, L. E.: Osseous abnormalities of thoracic cage seen in 40,000 consecutive chest photoroentgenograms. Am. J. Roentgenol. 51: 359–363, 1944. 27 Folkins, J. A.: Multiple dentigerous cysts in child of 10. J. Canad. Dent. A. 25: 140–145, 1959. 28 Frech, W. H.: Über Epidermoidcysten (Cholesteatome) der Kieferhöhle; kasuistischer Beitrag. Arch. Ohren-, Nasen- u. Kehlkopfh. 162: 304–317, 1953. 29 Gerke, J.: Multiple Zystenbildung im Kieferbereiche. Deutsche zahnärztl. Ztschr. 2: 501–508, 1947. 30 Gerke, J.: Über die maligne Entartung von Kieferzysten und anderen gutartigen Geschwülsten. Zahnärztl. Welt. 3: 1–8, 1948. 31 Gerke, J.: Personal communication, 1963. 32 Goldman, H. J.: Multiple benign cystic epithelioma; report of 10 cases in 1 family. J. A. M. A. 115: 2253–2257, 1940. 33 Gorlin, R. J., and Goltz, R. W.: Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib; syndrome. New England J. Med. 262: 908–912, 1960. 34 Gorlin, R. J.; Yunis, J. J., and Tuna, N.: Multiple nevoid basal cell carcinoma, odontogenic keratocysts and skeletal anomalies; syndrome. Acta Dermat.- Venereol. 43: 39–55, 1963. 35 Grellier, B.: Case of multiple dentigerous cysts. Proc. Roy. Soc. Med. 16: 43–44, 1922–1923. 36 Gross, P. P.: Epithelioma adenoides cysticum with follicular cysts of maxilla and mandible; report of case. J. Oral Surg. 11: 160–165, 1953. 37 Hauer, A.: Ein Cholesteatom im linken Unterkiefer unter einem retinierten Weisheitszahn. Oesterr. Ztschr. Stomatol. 24: 40–49, 1926. 38 Heidsieck, C.: Beitrag zu den im Kiefer liegenden Epidermoiden. Deutsche Zahn-, Mund- u. Kieferh. 18: 116–126, 1953. 39 Hermans, E. H.: Personal communication, 1963. 40 Hermans, E. H.: Grosfeld, J. C. M., and Valk, L. E. M.: Eine fünfte Phakomatoses; Nævus epitheliomatodes multiplex. Hautarzt 11: 160–164, 1960. 41 Hern, W.: [Case of multiple dentigerous cysts.] In Odontological Society of Great Britain, ordinary monthly meeting, February 5, 1894. Tr. Odontol. Soc. Great Britain 26: 89–104, 1894; 91–95. 42 Herzberg, J. J., and Wiskemann, A.: Die fünfte Phakomatose, Basalzellnaevus mit familiärer Belastung und Medulloblastom. Dermatologica 126: 106–123, 1963. 43 Hewer, T. F.: Primary epithelial tumours of jaw. J. Clin. Path. 5: 225–233, 1952. 44 Hewer, T. F.: Personal communication, 1963. 45 Holland, H. W.: Personal communication, 1963. 46 Howell, J. B.: Personal communication, 1963. 47 Howell, J. B., and Caro, M. R.: Basal-cell nevus; its relationship to multiple cutaneous cancers and associated anomalies of development. A. M. A. Arch. Dermat. 79: 67–80, 1959. 48 Ivy, R. H.: Multiple dentigerous cysts, with special reference to occurrence in siblings. Ann. Surg. 109: 114–125, 1939. 49 Jablonska, S.: Basaliome naevoider Herkunft (Naevobasaliome bzw. Basalzellnaevi). Hautarzt 12: 147–157, 1961. 50 Jarisch: Zur Lehre von den Hautgeschwülsten. Arch. Dermat. u. Syph. 28: 163–222, 1894. 51 Kallenberger, K.: Über das Vorkommen von sogenannten Cholesteatomen am Kiefer. Schweiz. Monatsschr. Zahnh. 63: 32–41, 1953. 52 Kirsch, T.: Pathogenetische Beziehungen zwischen Kieferzysten und Hautveränderungen unter besonderer Berücksichtigung der Hautkarzinomatose. Schweiz. Monatsschr. Zahnh. 66: 687–701, 1956. 53 Knight, J. S.: Personal communication, 1963. 54 Knight, J. S., and Manley, E. B.: Case of multiple cysts of mandible. Brit. Dent. J. 91: 209–212, 1951. 55 Knight, J. S., and Manley, E. B.: Formation of multiple dental cysts. Brit. Dent. J. 99: 419–423, 1955. 56 Kostečka, F.: Ein Cholesteatom im Unterkiefer. Ztschr. Stomatol. 27: 1102–1108, 1929. 57 Kraus, Z., and Vortel, V.: [Unilateral indolent basal cell naevus with comedones.] Ved. Praci Lek. Fak. Karlovy Univ. Hradec Kralove 3 (1): 58–65, 1960. Abstr. in Excerpta med. sect. 13 15: 121, 1961. 58 Lande, A.: Personal communication, 1963. 59 Lausecker, H.: Beitrag zu den Naevo-Epitheliomen. Arch. Dermat. u. Syph. 194: 639–666, 1952. 60 Lehnert, K.: Multiple Kieferzysten bei Atherom der Mundschleimhaut und hyperkeratotischen Hautveränderungen; kasuistischer Beitrag zur Ätiologie der Kieferzysten. Deutsche zahnärztl. Ztschr. 10: 214–219, 1955. 61 Limberg, A.: Case of multiple follicular cysts. Dental Cosmos 67: 343–345, 1925. 62 Macgregor, A. B.: Multiple dentigerous cysts. Brit. Dent. J. 79: 63–67, 1945. 63 Macgregor, A. B.: Personal communication, 1963. 64 Maddox, W. D.: Multiple Basal Cell Tumors, Jaw Cysts and Skeletal Defects; a Clinical Syndrome. M. S. thesis, University of Minnesota, 1962. Unpublished. 65 MARASCALCO: Personal communication, 1963. 66 Mayrhofer: Zweifache heterotope Follikularzyste. In Wissenschaftliche Ärztegesellschaft in Innsbruck; Sitzung vom 28. Juni 1912. Wien. Klin. Wchnschr. 26: 38–40, 1913; 39–40. 67 McKelvey, L. E.; Albright, C. R., and Prazak, G.: Multiple hereditary familial epithelial cysts of jaws with associated anomaly of trichoepithelioma; report of case. Oral Surg. 13: 111–116, 1960. 68 Montagna, W.: The Structure and Function of Skin, 2d ed. New York, N. Y. Academic Press Inc. 1962. 69 Mummery, J. H.: Case of multiple dentigerous cysts. Proc. Roy. Soc. Med. 16: 44–47, 1922–1923. 70 Myers, P. B., Bilateral dentigerous cysts of mandible. Brit. Dent. J. 74: 67–68, 1943. 71 Nisbet, T. W.: Multiple basal cell epithelioma originating from congenital pigmented basal cell Nevi. Arch. Dermat. & Syph. 47: 373–381, 1943. 72 Offenhauer, P.: Zur Deutung von Cholesteatomen und Epidermoiden bei multipler Zystenbildung im Kieferbereich. Deutsche Stomatol. 12: 435–446, 1962. 73 Oliver, C. H.: Case of multiple dentigerous cysts. Brit. Dent. J. 57: 591–592, 1934. 74 Oliver, R. M.: Basal–cell nevus. [Abstr.] A. M. A. Arch. Dermat. 81: 284–285, 1960. 75 Pautrier, L. M.: Epithéliomas næviques multiples de la face et du tronc. Ann. Dermat. et Syph. 7: 5–14, 1947. 76 Pedlar, J. A.: Personal communication, 1963. 77 Pekarsky, R. L.: Dentigerous cysts of jaws with unerupted teeth. Oral Surg. 3: 860–867, 1950. 78 Philipsen, H. P.: Om keratocyster (kolesteatomer) i kæberne. Tandlœgebladet 60: 963–980, 1956. 79 Pindborg, J. J., and Hansen, J.: Studies on odontogenic cyst epithelium; 2, clinical and roentgenologic aspects of odontogenic keratocysts. Acta Path. et Microbiol. Scandinav. 58: 283–294, 1963. 80 Pindborg, J. J.; Philipsen, H. P., and Henriksen, J.: Studies on odontogenic cyst epithelium; keratinization in odontogenic cysts. In E. O. Butcher, and R. F. Sognnaes, Eds.: Fundamentals of Keratinization. Washington, D. C. American Association for the Advancement of Science. 1962; pp. 151–160. 81 Radden, H. G., and Janes, B. V.: Multiple cysts of mandible; report of case. Oral Surg. 9: 1324–1329, 1956. 82 Rasmussen, P. E.: Follikulære kæbecyster, basalcelletumorer og knogleanomalier som led i et hereditæret syndrom. Nord. Med. 69: 606–612, 1963. 83 Rebello, J. A., and Savatard, J. E. M.: Basal cell naevi with bony cysts. Tr. North England Dermat. Soc. [1960]: 53–56, 1960. 84 Rodin, H. H.: Neurofibromatosis. A. M. A. Arch. Dermat. & Syph. 63: 530, 1951. 85 Rushton, M. A.: Cases of accelerated and retarded dentition. Brit. Dent. J. 71: 277–279, 1941. 86 Salman, I.: Cysts of jaws. J. Oral Surg. 9: 188–206, 1951. 87 Scarff, R. W., and Thomson, A. D.: Swellings of jaw. Brit. J. Surg. 45: 512–518, 1957–1958. 88 Schamberg, I. L.: Basal-cell nevi. [Abstr.] A. M. A. Arch. Dermat. 81: 269, 1960. 89 Scharnagel, I. M., and Pack, G. T.: Multiple basal cell epitheliomas in 5 year old child. Am. J. Dis. Child. 77: 647–651, 1949. 90 Seeman, G. F.: Report of 4 follicular cysts—dentigerous. Internal. J. Orthodont. 23: 1138–1140, 1987. 91 Sharland, R. J.: Case of multiple dentigerous cysts of mandible. Brit. Dent. J. 84: 35–36, 1948. 92 Sharland, R. J.: Personal communication, 1963. 93 Shear, M.: Primordial cysts. J. Dent. A. South Africa 15: 211–217, 1960. 94 Shear, M.: Personal communication, 1963. 95 Shlefstein, I. H. L.: Multiple cysts of jaws. Am. J. Orthodontics 29: 452–456, 1943. 96 Sprawson, E.: Case of multiple dentigerous cysts in mandible, and some remarks on pathology of such cysts. Proc. Roy. Soc. Med. 15: 56–64, 1921–1922. 97 Starup, U.: Tilfælde af multiple Follikulærcyster i Underkæben. Hospitalstid. 79: 881–887, 1936. 98 Stea, G.: Le cisti epidermoidi delle ossa mascellari. Minerva Stomatol. 9: 518–531, 1960. 99 Straith, F. E.: Hereditary epidermoid cyst of jaws. Am. J. Orthodontics 25: 673–691, 1939. 100 Summerill, F., and Hutton, J. G.: Multiple benign cystic epithelioma (epithelioma adenoides cysticum); with summary of literature. Arch. Dermat. & Syph. 26: 854–864, 1932. 101 Summerly, R.: Personal communication, 1963. 102 Talley, D. B.: Follicular cyst. Dent. Cosmos 67: 1200–1203, 1925. 103 Thies, W.; Dorn, H., and Weise, H. J.: Zur Frage der Naevobasaliome. Arch. Klin. u. Exper. Dermat. 210: 291–312, 1960. 104 Thoma, K. H.: Polycystoma. Oral Surg. 12: 484–488, 1959. 105 Thoma, K. H., and Blumenthal, F. R.: Heredity and cyst formation. Am. J. Orthodontics 32: 273–281, 1946. 106 Traenkle, H. L.: Epithelioma adenoides cysticum, trichoepithelioma and basal cell cancer; relation between these diseases, as shown by histologic studies of multiple benign cystic epithelioma. Arch. Dermat. & Syph. 42: 822–839, 1940; corr. 1174, 1940. 107 Ward, W. H.: Nævoid basal celled carcinoma associated with dyskeratosis of palms and soles; new entity. Australian J. Dermat. 5: 204–208, 1960. 108 Weidman, F. D., and Besancon, J. H.: Histologic differences in "syringoma" of face and shoulder; employment of wax reconstruction. Arch. Dermat. & Syph. 21: 279–293, 1930. 109 Wigginton, D. J.: Three cases of dental cysts in 1 family. Guy's Hosp. Gaz. 50: 179–180, 1936. 110 Williger: Über Zahnwurzelzysten. Deutsche zahnärztl. Wchnschr. 28: 124–130, 1925. 111 Worth, H. M.: Radiographic differential diagnosis. Brit. Dent. J. 63: 389–394, 1937. 112 Worth, H. M.: Principles and Practice of Oral Radiologic Interpretation. Chicago, Ill. Year Book Medical Publishers, Inc. 1963; pp. 448–449. 113 Bazex, A.; Dupré, A.; Parant, M., and Bessière, L.: Epithélio matose multiple, multiforme généralisée (type Ferrari). Bul. Soc. Franç. Dermat. et Syph. 67: 72–74, 1960. 114 Clendenning, W. E.; Block, J. B., and Radde, I. C.: Basal cell nevus syndrome. Arch. Dermat. 90: 38–53, 1964. 115 Clendenning, W. E.; Herdt, J. R., and Block, J. B.: Ovarian fibromas and mesenteric cysts; their association with hereditary basal cell cancer of skin. Am. J. Obst. & Gynec. 87: 1008–1012, 1963. 116 Cook, W. A.: Family pedigree—Cancer, cysts, and oligodontia. Dental Radiog. & Photog. 37: 27–35, 1964. 117 Maddox, W. D.; Winkelmann, R. K.; Harrison, E. G., Jr.; Devine, K. D., and Gibilisco, J. A.: Multiple nevoid basal cell epitheliomas, jaw cysts, and skeletal defects; clinical syndrome. J. A. M. A. 188: 106–111, 1964. 118 Pollard, J. J., and New, P. F. J.: Hereditary cutaneomandibular polyoncosis; syndrome of myriad basal-cell nevi of skin, mandibular cysts, and inconstant skeletal anomalies. Radiology 82: 840–849, 1964. 119 Swanson, A. E., and Jacks, Q. D.: Unusual propensity for odontogenic cyst formation. J. Canad. Dent. A. 27: 723–731, 1961. 120 Williamson, G. S., and Jackson, R.: Treatment of basal cell carcinoma by electrodesiccation and curettage. Canad. M. A. J. 86: 855–862, 1962. 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