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The role of dynein in retrograde axonal transport

1989; Elsevier BV; Volume: 12; Issue: 2 Linguagem: Inglês

10.1016/0166-2236(89)90138-0

1878-108X

Richard B. Vallee, Howard S. Shpetner, Bryce M. Paschal,

Cellular transport and secretion

Fast axonal transport is manifested at the sub-cellular level as the anterograde or retrograde movement of membrane-bounded organelles along microtubules. Earlier work implicated the protein kinesin as the motor for anterograde axonal transport. More recent work indicates that a brain microtubule-associated protein, MAP 1C, is responsible for retrograde transport. Of additional interest, MAP 1C has been found to be a cytoplasmic form of the ciliary and flagellar ATPase dynein, indicating a much more general functional role for this enzyme in cells than had been suspected.