On the mode of formation of tetrahydro-β-carbolines
1976; Elsevier BV; Volume: 18; Issue: 1 Linguagem: Inglês
10.1016/0024-3205(76)90277-0
ISSN1879-0631
AutoresHans Rommelspacher, H. Coper, Sabine Strauss,
Tópico(s)Synthesis and bioactivity of alkaloids
ResumoThe condensation of tetrahydro-β-carboline (TBC) takes place if serotonin is incubated with 5-MTHF and the cytosol fraction from rat brain as an enzymatic source. Such a formation occurs to a lesser extent if the enzyme(s) is omitted from the incubation mixture. The conditions of the enzymatic as well as the non-enzymatic mode of formation of TBC are investigated. It could be shown by addition of semicarbazide to the incubation medium that formaldehyde is an intermediate in the production of TBC. The biological significance of TBC will be discussed.
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