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The Development of Host-Type θ and TL Antigens in Nude Mice after Transplantation of a Neonatal Thymus

1975; Oxford University Press; Volume: 15; Issue: 1 Linguagem: Inglês

10.1093/icb/15.1.175

2162-4445

Berenice Kindred, Francis Loor,

Immune Cell Function and Interaction

Thymus cells from the BALB/c and AKR mouse strains can be distinguished by the 8 and TL surface antigens. When a BALB/c-nunu (athymic) mouse is grafted with a neonatal AKR thymus, the great majority of the cells of the grafted thymus retain AKR characteristics for about 12 days. Between day 12 and day 26 both host- and donor-type cells can be found, but after day 26 there are only host-type cells. The differentiation of host-type T cell precursors requires the presence of thymus epithelium and perhaps actual thymus structure.