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The Physiological Stimulus for the BarA Sensor Kinase

2010; American Society for Microbiology; Volume: 192; Issue: 7 Linguagem: Inglês

10.1128/jb.01685-09

1098-5530

Ricardo González, Adrián F. Álvarez, Tony Romeo, Dimitris Georgellis,

Cell death mechanisms and regulation

ABSTRACT The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end products formate and acetate provide a physiological stimulus for this TCS and thus link posttranscriptional regulation by the Csr system to the metabolic state of the cell.