Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Ovalbumin encapsulation into liposomes results in distinct degrees of oral immunization in mice

2008; Elsevier BV; Volume: 254; Issue: 1 Linguagem: Inglês

10.1016/j.cellimm.2008.07.001

1090-2163

Andréa C. Alves, Gilson Andrade Ramaldes, Mônica Cristina Oliveira, Valbert Nascimento Cardoso, T. A. Mota‐Santos, Ana Maria Caetano Faria, Célia Maria Ferreira Gontijo,

Immune Cell Function and Interaction

Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strategy is the usage of liposomes. Different parameters may influence the stability of liposomes in the gastrointestinal tract. Herein, we studied the immunological consequences of oral administration of liposome-encapsulated ovalbumin in different strains of mice using different liposomes. Our data demonstrated that ovalbumin liposomes improved the induction of oral immunization and the degree of improvement depended on the liposome type and on the strain of mice used. The mechanism responsible for this differential effect of liposomes depended on the site of antigen release and absorption. Therefore, some liposomes might be suitable as adjuvants for oral immunization, others for oral tolerance induction.