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The inhibition of Th17 immune response in vitro and in vivo by the carbosilane dendrimer 2G-NN16

2012; Elsevier BV; Volume: 33; Issue: 15 Linguagem: Inglês

10.1016/j.biomaterials.2012.02.018

1878-5905

Rafael Gras, Miguel Relloso, María I. García, F. Javier de la Mata, Rafael Gómez, Luis A. López‐Fernández, María Ángeles Muñoz‐Fernández,

Psoriasis: Treatment and Pathogenesis

We evaluated the 2G-NN16-carbosilane dendrimer activities in Th17 response as a potential therapy for Th17 deregulated pathologies. IL17A, IL17F, IL22, IL23 and other interleukins secreted by Th17 cells CD4+ cells were down regulated when cells were cultured in the presence of this dendrimer. Furthermore, IL17F and IL17A protein levels in splenocytes from mice pretreated with 2G-NN16 dendrimer in a Th17 induction mouse model were lower than those corresponding to PBS treated mice. Treatment of mice with 2G-NN16 inhibited the Th17 response causing much more pathogenicity as indicated by the increase in the number of Candida albicans colonies in the kidneys as compared to PBS-treated mice. All these results suggest a potential pharmacological application for this dendrimer in the therapy of Th17-mediated diseases.