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Risk of breast cancer among enlisted Army women occupationally exposed to volatile organic compounds

2005; Wiley; Volume: 48; Issue: 3 Linguagem: Inglês

10.1002/ajim.20201

1097-0274

Christopher P. Rennix, Margaret Quinn, Paul J. Amoroso, Ellen A. Eisen, David H. Wegman,

Health, Environment, Cognitive Aging

American Journal of Industrial MedicineVolume 48, Issue 3 p. 157-167 Article Risk of breast cancer among enlisted Army women occupationally exposed to volatile organic compounds†‡§ Christopher P. Rennix ScD, Corresponding Author Christopher P. Rennix ScD cprennix@mar.med.navy.mil Environmental Programs, Navy Environmental Health Center, Portsmouth, VirginiaNavy Environmental Health Center (NEHC EP), 620 John Paul Jones Circle Suite 1100, Portsmouth, VA 23708.Search for more papers by this authorMargaret M. Quinn ScD, Margaret M. Quinn ScD Work Environment Department, University of Massachusetts, Lowell, MassachusettsSearch for more papers by this authorPaul J. Amoroso MD, Paul J. Amoroso MD Total Army Injury/Health Outcomes Database, Military Performance Department, U.S. Army Research Institute for Environmental Medicine, Natick, MassachusettsSearch for more papers by this authorEllen A. Eisen ScD, Ellen A. Eisen ScD Work Environment Department, University of Massachusetts, Lowell, MassachusettsSearch for more papers by this authorDavid H. Wegman MD, MSOH, David H. Wegman MD, MSOH School of Health and Environment, University of Massachusetts, Lowell, MassachusettsSearch for more papers by this author Christopher P. Rennix ScD, Corresponding Author Christopher P. Rennix ScD cprennix@mar.med.navy.mil Environmental Programs, Navy Environmental Health Center, Portsmouth, VirginiaNavy Environmental Health Center (NEHC EP), 620 John Paul Jones Circle Suite 1100, Portsmouth, VA 23708.Search for more papers by this authorMargaret M. Quinn ScD, Margaret M. Quinn ScD Work Environment Department, University of Massachusetts, Lowell, MassachusettsSearch for more papers by this authorPaul J. Amoroso MD, Paul J. Amoroso MD Total Army Injury/Health Outcomes Database, Military Performance Department, U.S. Army Research Institute for Environmental Medicine, Natick, MassachusettsSearch for more papers by this authorEllen A. Eisen ScD, Ellen A. Eisen ScD Work Environment Department, University of Massachusetts, Lowell, MassachusettsSearch for more papers by this authorDavid H. Wegman MD, MSOH, David H. Wegman MD, MSOH School of Health and Environment, University of Massachusetts, Lowell, MassachusettsSearch for more papers by this author First published: 10 August 2005 https://doi.org/10.1002/ajim.20201Citations: 37 † This work was performed at Department of Work Environment, University of Massachusetts Lowell, Lowell, MA. ‡ Christopher P. Rennix is a Director, Margaret M. Quinn and Ellen A. Eisen are Professor, Paul J. Amoroso is a Project Director, and David H. Wegman is a Dean. § This article is a US Government work and, as such, is in the public domain in the United States of America. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background The military presents a unique opportunity to study the incidence of disease in a population with complete knowledge of person-time and occupation. Women in the Army are employed more frequently in non-traditional, industrial jobs such as auto mechanic and motor transport operators than in the general US population, increasing the probability of exposure to industrial chemicals. A cohort to investigate the risk of breast cancer among active duty Army women occupationally exposed to volatile organic chemicals (VOCs) was constructed. Methods Age-adjusted incidence rates for breast cancer were calculated for more than 270,000 enlisted women who served between 1980–1996. Twenty-one VOCs, described in previously published literature as having a potential risk of breast cancer, were identified in an Army industrial hygiene survey database. Job title histories were linked to workplace chemical evaluations conducted by Army industrial hygienists, which included a subjective exposure potential rating (high, medium, low, and none) for each VOC. Poisson regression analysis was used to evaluate the association between the exposure rating by job title and breast cancer. Results The incidence of breast cancer in the cohort was significantly elevated in women younger than 35 years of age, especially among black women, when compared to the age-specific rates in the general population. Women who worked in occupations with a moderate to high exposure potential to at least one VOC had a 48% increased risk (P < 0.05) of breast cancer while on active duty between 1980–1996 when compared to those women with low to no exposure potential. Conclusions This study provides preliminary evidence that exposure to one or more of the study VOCs is associated with an increased risk of breast cancer. Further substance-specific, quantitative analyses are warranted. Am. J. Ind. Med. 48:157–167, 2005. Published 2005 Wiley-Liss, Inc. Citing Literature Volume48, Issue3September 2005Pages 157-167 RelatedInformation