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The TODAY Study: An NIH Perspective on Its Implications for Research

2013; American Diabetes Association; Volume: 36; Issue: 6 Linguagem: Inglês

10.2337/dc13-0707

1935-5548

Barbara Linder, Judith Fradkin, Griffin P. Rodgers,

Diabetes and associated disorders

Once referred to as adult-onset diabetes, type 2 diabetes (T2D) has emerged in youth as a consequence of the worldwide increase in obesity. The development of T2D among young individuals has significant public health consequences as these youth are likely to manifest the complications of diabetes, including retinopathy, nephropathy, neuropathy, and cardiovascular disease, at a time that should be the most active and productive of their lives. In response to the emergence of T2D among youth in the mid-1990s, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health sought to foster research to understand and address this public health threat. Since most of our knowledge about the epidemiology of T2D in the pediatric population was based on small clinic-based reports, NIDDK partnered with the Centers for Disease Control and Prevention (CDC) to establish the SEARCH for Diabetes in Youth Study to provide population-based statistics for diabetes in U.S. youth (1). SEARCH data from 2002–2003 indicated that approximately 3,700 youth were being diagnosed annually with T2D (2). T2D is rarely seen in children younger than 10 years. In non-Hispanic white youth 10–19 years of age, T2D represents 15% of the new cases of diabetes. However, T2D predominates in 10- to 19-year-old minority youth, representing 86% of the new cases among American Indians, 70% among Asian/Pacific Islanders, 58% in blacks, and 46% in Hispanics. SEARCH is continuing to ascertain diabetes incidence and is poised to provide critical information on trends in the incidence for both type 1 diabetes and T2D among U.S. youth. SEARCH has also described in great detail the characteristics of U.S. youth with T2D. Perhaps of greatest concern is that 27% of the youth with T2D enrolled in …