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Cisplatin‐resistant metastatic hepatoblastoma: Complete response to carboplatin, etoposide, and liver transplantation

1993; Alan R. Liss, Inc.; Volume: 21; Issue: 7 Linguagem: Inglês

10.1002/mpo.2950210711

1096-911X

Liane Lockwood, David Heney, G R Giles, Ian Lewis, Clifford C. Bailey,

Lung Cancer Treatments and Mutations

Abstract A child with stage 4 hepatoblastoma failed to respond to treatment with cisplatin and adriamycin. She then showed a response to carboplatin with complete clearing of pulmonary metastases. Bilobar liver disease persisted, although significantly reduced in size. A liver transplant was subsequently performed and she remains in complete remission 36 months later. After the first course of carboplatin, there was a dramatic rise in alpha‐feto protein which then fell exponentially. Carboplatin warrants further study in hepatoblastoma. © 1993 Wiley‐Liss, Inc.