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Boc Groups as Protectors and Directors for Ir-Catalyzed C−H Borylation of Heterocycles

2009; American Chemical Society; Volume: 74; Issue: 23 Linguagem: Inglês

10.1021/jo901822b

1520-6904

Venkata A. Kallepalli, Feng Shi, Sulagna Paul, Edith N. Onyeozili, Robert E. Maleczka, Milton R. Smith,

Catalytic Cross-Coupling Reactions

Ir-catalyzed C−H borylation is found to be compatible with Boc protecting groups. Thus, pyrroles, indoles, and azaindoles can be selectively functionalized at C−H positions β to N. The Boc group can be removed on thermolysis or left intact during subsequent transformations.