Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions
2013; National Academy of Sciences; Volume: 110; Issue: 44 Linguagem: Inglês
10.1073/pnas.1221535110
ISSN1091-6490
AutoresJérémy Baudhuin, Julie Migraine, Valérie Faivre, Laure Loumagne, Anne‐Claire Lukaszewicz, Didier Payen, Benoı̂t Favier,
Tópico(s)Cell Adhesion Molecules Research
ResumoSignificance Neutrophils are key components of inflammatory responses and immune defense against pathogens. Neutrophil functions are tightly controlled by surface receptors. Our study shows that the engagement of immunoglobulin-like transcript 4 (ILT4) inhibitory receptor impairs phagocytosis and respiratory burst of neutrophils. Moreover, we found that following induction of neutrophil granule exocytosis, ILT4 expression increases as a result of the rapid translocation of an intracellular pool to the cell surface. This increase of ILT4 expression enhances the ILT4-mediated inhibition of neutrophil activity. Finally, ILT4 up-regulation on neutrophils is impaired in sepsis patients. These results reveal a unique mechanism of regulation of neutrophil functions through ILT4 and its exocytosis that may have implications in inflammatory disorders and immune responses.
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