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The dendritic cell in allergic airway diseases: a new player to the game

2001; Wiley; Volume: 31; Issue: 2 Linguagem: Inglês

10.1046/j.1365-2222.2001.01061.x

1365-2222

Bart N. Lambrecht,

T-cell and B-cell Immunology

Clinical & Experimental AllergyVolume 31, Issue 2 p. 206-218 The dendritic cell in allergic airway diseases: a new player to the game B. N. Lambrecht, B. N. Lambrecht Department of Pulmonary and Critical Care Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The NetherlandsSearch for more papers by this author B. N. Lambrecht, B. N. Lambrecht Department of Pulmonary and Critical Care Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The NetherlandsSearch for more papers by this author First published: 07 July 2008 https://doi.org/10.1046/j.1365-2222.2001.01061.xCitations: 44 Bart N. Lambrecht, Department of Pulmonary and Critical Care Medicine, Erasmus University Rotterdam (Room Ee2263), Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Humbert M, Menz G & Ying S et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999; 20: 528–33.DOI: 10.1016/s0167-5699(99)01535-2 2 Haczku A, Moqbel R & Jacobson M et al. T-cells subsets and activation in bronchial mucosa of sensitized Brown- Norway rats after single allergen exposure. Immunology 1995; 85: 591–7. 3 Haczku A, Macary P & Huang TJ et al. Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in Brown-Norway rats. Immunology 1997; 91: 176–85. 4 Nakajima H, Iwamoto I & Tomoe S et al. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respiratory Dis 1992; 146: 374–7. 5 Kon OM, Sihra BS & Compton CH et al. Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma. Lancet 1998; 352: 1109–13.DOI: 10.1016/s0140-6736(97)12261-9 6 Banchereau J, Briere F & Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767–811. 7 Havenith CEG, Van Miert PPMC & Breedijk AJ et al. Migration of dendritic cells into the draining lymph nodes of the lung after intratracheal instillation. Am J Respir Cell Mol Biol 1993; 9: 484–8. 8 Sallusto F, Cella M & Danieli C et al. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med 1995; 182: 389–400. 9 Masten BJ & Lipscomb MF. Comparison of lung dendritic cells and B cells in stimulating naive antigen-specific T cells. J Immunol 1999; 162: 1310–7. 10 Geijtenbeek TBH, Torensma R & Van Vliet SJ et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100: 575–85. 11 Lanzavecchia A & Sallusto F. From synapses to immunological memory: the role of sustained T cell stimulation. Curr Opin Immunol 2000; 12: 92–8.DOI: 10.1016/s0952-7915(99)00056-4 12 Caux C & Massacrier C, Vanbervliet et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994; 180: 1263–72. 13 Ohshima Y, Tanaka Y & Tozawa H et al. Expression and function of OX40 ligand on human dendritic cells. J Immunol 1997; 159: 3838–48. 14 Anderson DM, Maraskovsky E & Billingsley WL et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997; 390: 175–9.DOI: 10.1038/36593 15 Lambrecht BN, Germonpre PR & Everaert EG et al. Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation. Eur J Immunol 1999; 29: 3815–25.DOI: 10.1002/(sici)1521-4141(199912)29:12 3.0.co;2-# 16 Schon-Hegrad MA, Oliver J & McMenamin PG et al. Studies on the density, distribution and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J Exp Med 1991; 173: 1345–56. 17 Holt PG, Oliver J & McMenamin C et al. Studies on the surface phenotype and functions of dendritic cells in parenchymal lung tissue of the rat. Immunology 1992; 75: 582–7. 18 Van Haarst JMW, Hoogsteden HC & De Wit HJ et al. Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties. Am J Respir Cell Mol Biol 1994; 11: 344–50. 19 Holt PG, Haining S & Nelson DJ et al. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol 1994; 153: 256–61. 20 Suda T, McCarthy K & Vu Q et al. Dendritic cell precursors are enriched in the vascular compartment of the lung. Am J Respir Cell Mol Biol 1998; 19: 728–37. 21 Power CA, Church DJ & Meyer A et al. Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3 alpha from lung dendritic cells. J Exp Med 1997; 186: 825–35. 22 Yang D, Chertov O & Bykovskaia SN et al. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999; 286: 525–8.DOI: 10.1126/science.286.5439.525 23 Dieu MC, Vanbervliet B & Vicari A et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med 1998; 188: 373–86. 24 Cochand L, Isler P & Songeon F et al. Human lung dendritic cells have an immature phenotype with efficient mannose receptors. Am J Respir Cell Mol Biol 1999; 21: 547–54. 25 Stumbles PA, Thomas JA & Pimm CL et al. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med 1998; 188: 2019–31. 26 Sparwasser T, Koch ES & Vabulas RM et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 1998; 28: 2045–54.DOI: 10.1002/(sici)1521-4141(199806)28:06 3.3.co;2-# 27 Cyster JG. Chemokines and cell migration in secondary lymphoid organs. Science 1999; 286: 2098–102.DOI: 10.1126/science.286.5447.2098 28 Lambrecht BN, Pauwels RA & Fazekas De St Groth B. Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model. J Immunol 2000; 164: 2937–46. 29 Lambrecht BN, De Veerman M & Coyle AJ et al. Dendritic cells induce Th2 responses to inhaled antigen leading to eosinophilic airway inflammation. J Clin Invest 2000; 106: 551–9. 30 Adema GJ, Hartgers F & Verstraten R et al. A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 1997; 387: 713–7.DOI: 10.1038/42716 31 Sallusto F, Mackay CR & Lanzavecchia A. The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 2000; 18: 593–620. 32 Upham JW, Holt BJ & Baronhay MJ et al. Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium. Clin Exp Allergy 1995; 25: 634–42. 33 Abbas AK, Murphy KM & Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787–93. 34 Erb KJ. Atopic disorders: a default pathway in the absence of infection? Immunol Today 1999; 20: 317–22.DOI: 10.1016/s0167-5699(99)01475-9 35 Kalinski P, Hilkens CM & Wierenga EA et al. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 1999; 20: 561–7.DOI: 10.1016/s0167-5699(99)01547-9 36 Macatonia SE, Hosken NA & Litton M et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4 (+) T cells. J Immunol 1995; 154: 5071–9. 37 Stoll S, Jonuleit H & Schmitt E et al. Production of functional IL-18 by different subtypes of murine and human DC. DC-derived IL-18 enhances IL-12-dependent Th1 development Eur J Immunol 1998; 28: 3231–9.DOI: 10.1002/(sici)1521-4141(199810)28:10 3.0.co;2-q 38 Le Gros G, Ben-Sasson SZ & Seder R et al. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 1990; 172: 921–9. 39 Hashimoto S, Suzuki T & Dong HY et al. Serial analysis of gene expression in human monocyte-derived dendritic cells. Blood 1999; 94: 845–52. 40 DeSmedt T, Vanmechelen M & DeBecker G et al. Effect of interleukin-10 on dendritic cell maturation and function. Eur J Immunol 1997; 27: 1229–35. 41 Kalinski P, Hilkens CMU & Snijders A et al. IL-12 deficient dendritic cells, generated in the presence of prostaglandin E2, promote Type 2 cytokine production in maturing human naive T helper cells. J Immunol 1997; 159: 28–35. 42 Whelan M, Harnett MM & Houston KM et al. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J Immunol 2000; 164: 6453–60. 43 Comoy EE, Pestel J & Duez C et al. The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-gamma. J Immunol 1998; 160: 2456–62. 44 Salomon B & Bluestone JA. LFA−1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol 1998; 161: 5138–42. 45 Tanaka H, Demeure C & Rubio M et al. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: role of stimulator/responder ratio. J Exp Med 2000; 192: 405–11. 46 Hutloff A, Dittrich AM & Beier KC et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 1999; 397: 263–6.DOI: 10.1038/16717 47 Rissoan MC, Soumelis V & Kadowaki N et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283: 1183–6.DOI: 10.1126/science.283.5405.1183 48 Maldonado-Lopez R, De Smedt T & Michel P et al. CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med 1999; 189: 587–92. 49 Lambrecht BN, Peleman RA & Bullock GR et al. Sensitization to inhaled antigen by intratracheal instillation of dendritic cells. Clin Exp Allergy 2000; 30: 214–24.DOI: 10.1046/j.1365-2222.2000.00818.x 50 Krug N, Madden AE & Redington AE et al. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol 1996; 14: 319–26. 51 Seymour BWP, Gershwin LJ & Coffman RL. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8 (+) or T cell receptor (TCR)- gamma/delta (+) T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 1998; 187: 721–31. 52 Stampfli MR, Wiley RE & Scott Neigh G et al. GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice. J Clin Invest 1998; 102: 1704–14. 53 Yamamoto N, Suzuki S & Shirai A et al. Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice. Eur J Immunol 2000; 30: 316–26.DOI: 10.1002/(sici)1521-4141(200001)30:01 3.3.co;2-d 54 Constant S, Lee KS & Bottomly K. Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation. Eur J Immunol 2000; 30: 840–7.DOI: 10.1002/(sici)1521-4141(200003)30:03 3.0.co;2-a 55 Constant SL & Bottomly K. Induction of TH1 and TH2, CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997; 15: 297–322. 56 Prescott SL, Macaubas C & Holt BJ et al. Environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998; 160: 4730–7. 57 Yabuhara A, Macaubas C & Prescott SL et al. TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy 1997; 27: 1261–9. 58 Baldini M, Lohman IC & Halonen M et al. A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20: 976–83. 59 Arbour NC, Lorenz E & Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187–91.DOI: 10.1038/76048 60 Erb KJ, Holloway JW & Sobeck A et al. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia. J Exp Med 1998; 187: 561–9. 61 Tulic MK, Wale JL & Holt PG et al. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000; 22: 604–12. 62 Kline JN, Waldschmidt TJ & Businga TR et al. Modulation of airway inflammation by CpG oligodesoxynucleotides in a murine model of asthma. J Immunol 1998; 160: 2555–9. 63 Moller GM, Overbeek SE & VanHeldenMeeuwsen CG et al. Increased numbers of dendritic cells in the bronchial mucosa of atopic asthmatic patients: downregulation by inhaled corticosteroids. Clin Exp Allergy 1996; 26: 517–24. 64 Tunon Lara JM, Redington AE & Bradding P et al. Dendritic Cells in normal and asthmatic airways: expression of the alfa subunit of the high affinity immunoglobulin E receptor. Clin Exp Allergy 1996; 26: 648–55. 65 Bellini A, Vittori E & Marini M et al. Intraepithelial dendritic cells and selective activation of Th2-like lymphocytes in patients with atopic asthma. Chest 1993; 103: 997–1005. 66 Bertorelli G, Bocchino V & Zhou X et al. Dendritic cell number is related to IL-4 expression in the airways of atopic asthmatic subjects. Allergy 2000; 55: 449–54. 67 Lambrecht BN, Carro-Muino I & Vermaelen K et al. Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats. Am J Respir Cell Mol Biol 1999; 20: 1165–74. 68 Sozzani S, Sallusto F & Luini W et al. Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J Immunol 1995; 155: 3292–5. 69 McWilliam AS, Napoli S & Marsh AM et al. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J Exp Med 1996; 184: 2429–32. 70 Upham JW, Wood L & Denburg JA et al. Circulating dendritic cells and asthma: rapid response to inhaled allergen. Am J Respir Crit Care Med 1999; 159: 854(A). 71 Randolph GJ, Beaulieu S & Lebecque S et al. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 1998; 282: 480–3. 72 Hammad H, Duez C & Fahy O et al. Human dendritic cells in the severe combined immunodeficiency mouse model: their potentiating role in the allergic reaction. Lab Invest 2000; 80: 605–14. 73 Tazi A, Bouchonnet F & Grandsaigne M et al. Evidence that GM-CSF regulates the distribution and differentaited state of DC/LC in human lung and lung cancers. J Clin Invest 1993; 91: 566–76. 74 Brossart P, Grunebach F & Stuhler G et al. Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor. Blood 1998; 92: 4238–47. 75 Lambrecht BN, Salomon B & Klatzmann D et al. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol 1998; 160: 4090–7. 76 Djukanovic R. The role of co-stimulation in airway inflammation. Clin Exp Allergy 2000; 30: S46–S50. 77 Tsuyuki S, Tsuyuki J & Einsle K et al. Costimulation through B7–2 (CD86) is required for the induction of a lung mucosal T helper cell, 2 (TH2) immune response and altered airway responsiveness. J Exp Med 1997; 185: 1671–9. 78 Maurer D, Fiebiger E & Reininger B et al. Fcε receptor I on dendritic cells delivers IgE-bound multivalen antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol 1998; 161: 2731–9. 79 Van der Heijden FL, Van Neerven RJ & Van Katwijk M et al. Serum-IgE-facilitated allergen presentation in atopic disease. J Immunol 1993; 150: 3643–50. 80 Coyle AJ, Wagner K & Bertrand C et al. Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody. J Exp Med 1996; 183: 1303–10. 81 Bjorck P, Banchereau J & FloresRomo L. CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells. Int Immunol 1997; 9: 365–72.DOI: 10.1093/intimm/9.3.365 82 Mahnke K, Bhardwaj RS & Luger TA et al. Interaction of murine dendritic cells with collagen up-regulates allostimulatory capacity, surface expression of heat stable antigen, and release of cytokines. J Leuk Biol 1996; 60: 465–72. 83 Kodaira Y, Nair SK & Wrenshall LE et al. Phenotypic and functional maturation of dendritic cells mediated by heparan sulfate. J Immunol 2000; 165: 1599–604. 84 Imai T, Nagira M & Takagi S et al. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 1999; 11: 81–8.DOI: 10.1093/intimm/11.1.81 85 Lieberam I & Forster I. The murine beta-chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4+ T cells. Eur J Immunol 1999; 29: 2684–94.DOI: 10.1002/(sici)1521-4141(199909)29:09 3.0.co;2-y 86 Zhou LJ & Tedder TF. A distinct pattern of cytokine gene expression by human CD83 (+) blood dendritic cells. Blood 1995; 86: 3295–301. 87 Ludewig B, Odermatt B & Landmann S et al. Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med 1998; 188: 1493–501. 88 Chvatchko Y, Kosco-Vilbois MH & Herren S et al. Germinal center formation and local immunoglobulin E (IgE) production in the lung after an airway antigenic challenge. J Exp Med 1996; 184: 2353–60. 89 Scharenberg AM & Kinet J-P. Is localized immunoglobulin E synthesis the problem? Current Biol 1994; 4: 140–2. 90 Hoogsteden HC, Verhoeven GT & Lambrecht BN et al. Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate. Clin Exp Allergy 1999; 29(S2): 116–24. 91 Brokaw JJ, White GW & Baluk P et al. Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa. Am J Respir Cell Mol Biol 1998; 19: 598–605. 92 Van Den Heuvel MM, Van Beek NM & Broug-Holub E et al. Glucocorticoids modulate the development of dendritic cells from blood precursors. Clin Exp Immunol 1999; 115: 577–83.DOI: 10.1046/j.1365-2249.1999.00811.x 93 Holt PG & Thomas JA. Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells. Immunology 1997; 91: 145–50. 94 Vieira PL, Kalinski P & Wierenga EA et al. Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential. J Immunol 1998; 161: 5245–51. 95 Gantner F, Schudt C & Wendel A et al. Characterization of the phosphodiesterase (PDE) pattern of in vitro-generated human dendritic cells (DC) and the influence of PDE inhibitors on DC function. Pulm Pharmacol Ther 1999; 12: 377–86.DOI: 10.1006/pupt.1999.0220 Citing Literature Volume31, Issue2February 2001Pages 206-218 ReferencesRelatedInformation