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Suppository formulation of amodiaquine - In vitro release characteristics

1991; Taylor & Francis; Volume: 17; Issue: 2 Linguagem: Inglês

10.3109/03639049109043827

1520-5762

Emmanuel O. Akala, Adesoji R Adedoyin, Festus A. Ogunbona,

Pharmacology and Obesity Treatment

AbstractIn vitro release characteristics of amodiaquine hydrochloride from suppositories were studied. Results showed that water soluble bases (polyethylene glycol and glycero-gelatin) and water miscible synthetic fatty base (Witepsol W45) are superior to natural fatty bases (theobroma oil and shea butter) in terms of their ability to release amodiaquine hydrochloride.The in vitro availability of amodiaquine from polyethylene glycol suppository (the suppository which gave the highest rate and extent of release) was compared with its in vitro availability from tablets (CamoquinR) under the same experimental conditions. Polyethylene glycol suppository was found to be superior to the tablet.