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THE PYROGENIC RESPONSE TO ENDOTOXIN IN WARFARIN‐TREATED RABBITS

1971; Wiley; Volume: 79B; Issue: 2 Linguagem: Inglês

10.1111/j.1699-0463.1971.tb02147.x

0365-5563

Jostein Haugen,

Metabolomics and Mass Spectrometry Studies

No difference was found between warfarin‐treated and untreated rabbits with regard to the pyrogenic response to Salmonella typhi endotoxin by comparison of the contours of the fever curves, the fever indices, the latent periods and the various temperatures (1‐hr, 3‐hr and maximum temperature). A constant low coagulation activity is therefore of no consequence to the pyrogenic reaction, provided the endotoxin is intravenously administered. This strongly indicates that the endotoxin‐induced alterations of the blood coagulability have no decisive influence on the pyrogenic response. The dose‐response relationship was more reliably determined in tolerant than in nontolerant rabbits. The fever index seemed to be the most reliable of the response parameters in discriminating between doses. The relation between the blood coagulability and the R.E.S. function is discussed.