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Furanocembranoids from the Soft Corals Sinularia asterolobata and Litophyton arboreum

2008; Wiley; Volume: 5; Issue: 11 Linguagem: Inglês

10.1002/cbdv.200890210

1612-1880

Daniela Grote, Hans‐Martin Dahse, Karlheinz Seifert,

Synthetic Organic Chemistry Methods

Abstract The new cembranoid diterpene danielid ( 1 ) along with 3 α ‐ethoxyfuranocembranoid 2 , pukalide ( 3 ), 13 α ‐acetoxypukalide ( 4 ), furanocembranoid 5 , and furanosesquiterpene 6 have been isolated from the soft coral Sinularia asterolobata. The furanocembranoid diterpene 11 β ,12 β ‐epoxypukalide ( 7 ) and the sesquiterpene (−)‐bicyclogermacrene ( 8 ) have been obtained from the soft coral Litophyton arboreum. The structures were elucidated primarily by NMR spectroscopy. The furanocembranoids 2, 4 , and 5 show good antiproliferative activities against the cell lines L‐929 and K‐562, and weak cytotoxic effects on HeLa cells.