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Strategy and model building in the fourth dimension: a null model for genotype × age interaction as a Gaussian stationary stochastic process

2003; BioMed Central; Volume: 4; Issue: S1 Linguagem: Inglês

10.1186/1471-2156-4-s1-s34

2730-6844

Vincent P. Diego, Laura Almasy, Thomas D. Dyer, Júlia Maria Pavan Soler, John Blangero,

Gene Regulatory Network Analysis

Abstract Background Using univariate and multivariate variance components linkage analysis methods, we studied possible genotype × age interaction in cardiovascular phenotypes related to the aging process from the Framingham Heart Study. Results We found evidence for genotype × age interaction for fasting glucose and systolic blood pressure. Conclusions There is polygenic genotype × age interaction for fasting glucose and systolic blood pressure and quantitative trait locus × age interaction for a linkage signal for systolic blood pressure phenotypes located on chromosome 17 at 67 cM.