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Investigation of DNA methylation by direct electrocatalytic oxidation

2010; Royal Society of Chemistry; Volume: 46; Issue: 41 Linguagem: Inglês

10.1039/c0cc00983k

1364-548X

Po Wang, Zhibin Mai, Zong Dai, Xiaoyong Zou,

DNA and Nucleic Acid Chemistry

A rapid, convenient and accurate method for the assessment of DNA methylation status is presented based on the direct electrocatalytic oxidation of DNA bases without any bisulfite conversion, PCR amplification or labeling procedures.