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Hypospadias and Intake of Nutrients Related to One-Carbon Metabolism

2008; Lippincott Williams & Wilkins; Volume: 181; Issue: 1 Linguagem: Inglês

10.1016/j.juro.2008.09.041

1527-3792

Suzan L. Carmichael, Wei Yang, Adolfo Correa, Richard S. Olney, Gary M. Shaw,

Birth, Development, and Health

No AccessJournal of UrologyPediatric Urology1 Jan 2009Hypospadias and Intake of Nutrients Related to One-Carbon Metabolism Suzan L. Carmichael, Wei Yang, Adolfo Correa, Richard S. Olney, Gary M. Shaw, and National Birth Defects Prevention Study Suzan L. CarmichaelSuzan L. Carmichael California Research Division, March of Dimes Foundation, Oakland, California , Wei YangWei Yang California Research Division, March of Dimes Foundation, Oakland, California , Adolfo CorreaAdolfo Correa National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia , Richard S. OlneyRichard S. Olney National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia , Gary M. ShawGary M. Shaw California Research Division, March of Dimes Foundation, Oakland, California , and National Birth Defects Prevention Study View All Author Informationhttps://doi.org/10.1016/j.juro.2008.09.041AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examined whether hypospadias is associated with maternal intake of folic acid containing vitamin/mineral supplements or dietary intake of nutrients related to one-carbon metabolism (folate, choline, vitamins B12 and B6, thiamine, riboflavin, methionine and zinc). Materials and Methods: The study included births from October 1997 to December 2003 that were part of the National Birth Defects Prevention Study. Diet was assessed by food frequency questionnaire during maternal telephone interviews. Analyses included 915 cases with second or third degree hypospadias (urethra opened at the penile shaft, scrotum or perineum) and 2,266 male, liveborn, nonmalformed controls. All ORs and 95% CIs were estimated from logistic regression models that included several potential confounders. Nutrient based analyses also included energy intake. Results: Hypospadias risk was not associated with supplement use (adjusted ORs were 1.2, 95% CI 0.9–1.6 for intake beginning in the month before or the first month of pregnancy and 1.1, 95% CI 0.8–1.4 for intake beginning in the second or third month, relative to no intake). Among women who took supplements reduced hypospadias risk was associated with higher dietary intakes of choline, methionine and vitamin B12. The respective ORs (CIs) for the highest vs lowest quartiles were 0.7 (0.5–1.1), 0.6 (0.4–0.9) and 0.7 (0.5–1.0). Among women who did not take supplements increased risk of hypospadias was associated with higher vitamin B12 intake. 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Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 1January 2009Page: 315-321 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsfolic acidhypospadiasmaternal nutrition physiologyAcknowledgmentsCalifornia Department of Public Health, Maternal Child and Adolescent Health Division provided surveillance data from California for this study.MetricsAuthor Information Suzan L. Carmichael California Research Division, March of Dimes Foundation, Oakland, California More articles by this author Wei Yang California Research Division, March of Dimes Foundation, Oakland, California More articles by this author Adolfo Correa National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia More articles by this author Richard S. Olney National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia More articles by this author Gary M. Shaw California Research Division, March of Dimes Foundation, Oakland, California More articles by this author National Birth Defects Prevention Study More articles by this author Expand All Advertisement PDF downloadLoading ...