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Movement and reaction times and fine coordination tasks following pallidotomy

1999; Wiley; Volume: 14; Issue: 1 Linguagem: Inglês

10.1002/1531-8257(199901)14

1531-8257

Joseph Jankovic, Lea Ben‐Arie, Kenneth S. Schwartz, Kim Chen, Myrna M. Khan, Eugene C. Lai, Joachim K. Krauss, Robert G. Grossman,

Botulinum Toxin and Related Neurological Disorders

Movement DisordersVolume 14, Issue 1 p. 57-62 Article Movement and reaction times and fine coordination tasks following pallidotomy Joseph Jankovic MD, Corresponding Author Joseph Jankovic MD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Baylor College of Medicine, 6550 Fannin #1801, Houston, TX 77030, U.S.A.Search for more papers by this authorLea Ben-Arie BS, Lea Ben-Arie BS Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorKenneth Schwartz PA, Kenneth Schwartz PA Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorKim Chen MS, Kim Chen MS Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorMyrna Khan PhD, Myrna Khan PhD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorEugene C. Lai MD, PhD,, Eugene C. Lai MD, PhD, Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorJoachim K. Krauss MD, Joachim K. Krauss MD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorRobert Grossman MD, Robert Grossman MD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this author Joseph Jankovic MD, Corresponding Author Joseph Jankovic MD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Baylor College of Medicine, 6550 Fannin #1801, Houston, TX 77030, U.S.A.Search for more papers by this authorLea Ben-Arie BS, Lea Ben-Arie BS Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorKenneth Schwartz PA, Kenneth Schwartz PA Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorKim Chen MS, Kim Chen MS Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorMyrna Khan PhD, Myrna Khan PhD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorEugene C. Lai MD, PhD,, Eugene C. Lai MD, PhD, Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorJoachim K. Krauss MD, Joachim K. Krauss MD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this authorRobert Grossman MD, Robert Grossman MD Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, U.S.A.Search for more papers by this author First published: 22 January 2001 https://doi.org/10.1002/1531-8257(199901)14:1 3.0.CO;2-XCitations: 32AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract The effect of a unilateral, microelectrode-guided lesion in the globus pallidum internum (GPi) was evaluated in 41 patients (21 women) with moderately advanced Parkinson's disease (PD). The mean age was 60.3 ± 9.0 years (range, 40–74) and the mean symptom duration was 14.7 ± 5.3 years (range, 4–25). In addition to clinical ratings, movement time (MT) and reaction time (RT) tests were performed at baseline and 3 months after surgery during the "practically defined off" state (more than 12 hours after the last dose of levodopa). Improvement occurred bilaterally with more robust and statistically significant improvement on the contralateral side in all RT tests. Simple reaction time (SRT) improved by 14.5% (p < 0.001) and the choice reaction time (CRT) by 12.2% (p < 0.001) when the arm contralateral to the pallidotomy side was tested. There was a trend toward improvement in the ipsilateral arm. The MT, determined by repetitive movement between two adjacent targets, improved by 24% contralaterally (p < 0.0001) and by 12% ipsilaterally (p < 0.005). In addition, the Purdue Pegboard (PP) test scores, used to evaluate hand dexterity, improved on the contralateral side by 35.5% (p < 0.0002) but there was no statistically significant ipsilateral improvement. To the extent that MT and RT are quantitative measures of bradykinesia, our study provides evidence that this parkinsonian feature improves after pallidotomy. Citing Literature Volume14, Issue1January 1999Pages 57-62 RelatedInformation