Entropy maps characterize drug effects on brain dynamics in Alzheimer's disease
1998; Elsevier BV; Volume: 253; Issue: 1 Linguagem: Inglês
10.1016/s0304-3940(98)00603-x
ISSN1872-7972
AutoresLaurent Pézard, Jacques Martinerie, Francisco J. Varela, Florence Bouchet, David Guez, Christian Derouesné, Bernard Renault,
Tópico(s)Fractal and DNA sequence analysis
ResumoNon-linear quantifiers of brain electrical dynamics (entropy maps computed from the degradation of temporal forecasting of EEG signals) were studied in relation to drug treatment of Alzheimer's disease. A placebo condition was compared to three drug doses (50, 100 and 200 mg). A significant general effect of the drug was found when compared to placebo and specific contrasts between placebo and each of the three drug doses only reveal a significant entropy increase for the highest dose. These effects were localized bilaterally in fronto-temporal areas and support changes in the dynamics of the cerebral structures involved in memory processes.
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